Evidence map›Paper›PMID 27642657›Full record

ArticleEmotion (Washington, D.C.)2017

Anxiety-mediated facilitation of behavioral inhibition: Threat processing and defensive reactivity during a go/no-go task.

Christian Grillon, Oliver J Robinson, Marissa Krimsky, Katherine O'Connell, Gabriella Alvarez, Monique Ernst

Registry-linked trialAbstract read
In one paragraph

Article in Emotion (Washington, D.C.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00026559 (Effects of Arousal and Stress on Classical Conditioning), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00026559 nacompletednot on this map

Effects of Arousal and Stress on Classical Conditioning

TypeinterventionalSponsorNational Institute of Mental Health (NIMH)Ran2001 to 2022Enrolled1,418ConditionsHealthy VolunteersArmsShock Device, Auditory Startle Device
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christian GrillonSection on Neurobiology of Fear and Anxiety.ORCID 0000-0002-0625-260X
Oliver J RobinsonInstitute of Cognitive Neuroscience, University College London.ORCID 0000-0002-3100-1132
Marissa KrimskyDepartment of Psychology, University of Miami.
Katherine O'ConnellInterdisciplinary Program in Neuroscience, Georgetown University.
Gabriella AlvarezSection on Neurobiology of Fear and Anxiety.
Monique ErnstSection on Neurobiology of Fear and Anxiety.

Funding

The Psychophysiology Of Fear And AnxietyZIAMH002798 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GRILLON, CHRISTIAN · 2009 to 2022
$29.0M
Predoctoral Training in Intergrative NeuroscienceT32NS041231 · NINDS · GEORGETOWN UNIVERSITY · PI Ludise Malkova, Ashley S VanMeter · 2001 to 2026
$6.8M
Intramural NIH HHS ZIA MH002798Medical Research Council MR/K024280/1NINDS NIH HHS T32 NS041231
6 · The paper itself

Abstract

Anxiety can be broken down into multiple facets including behavioral components, such as defensive reactivity, and cognitive components, such as distracting anxious thoughts. In a previous study, we showed that anticipation of unpredictable shocks facilitated response inhibition to infrequent no-go trials during a go/no-go task. The present study extends this work to examine the distinct contribution of defensive reactivity, measures with fear-potentiated startle, and anxious thought, assessed with thought probes, on go and no-go performance. Consistent with our prior findings, shock anticipation facilitated response inhibition (i.e., reduced errors of commission) on the no-go trials. Regression analyses showed that (a) no-go accuracy was positively associated with fear-potentiated startle and negatively associated with threat-related/task-unrelated thoughts and (b) go accuracy correlated negatively with fear-potentiated startle. Thus, while the present findings confirm the influence of anxiety on response inhibition, they also show that such influence reflects the balance between the positive effect of defensive reactivity and the negative effect of distracting anxious thoughts. (PsycINFO Database Record

Indexed as

Inhibition, PsychologicalAdultAnxietyFearFemaleHumansMaleNeuropsychological TestsReflex, StartleYoung Adult

Identifiers

PMID27642657
PMCPMC5328922

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.