ArticleJournal of diabetes research2016
Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Impact of Dietary Factors during Pregnancy on the Development of Islet Autoimmunity and Type 1 Diabetes: A Systematic Literature Review.Nutrients · 2023Pooled it
- Diet, gut microbiome, and type 1 diabetes: from risk to translational opportunity.Gut microbes · 2026Review
- Obstetrical outcomes in pregnant patients following a gluten-free diet: A prospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Probiotic treatment with viable α-galactosylceramide-producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice.Journal of diabetes · 2024Article
- Article
- Failure to replicate the diabetes alleviating effect of a maternal gluten-free diet in non-obese diabetic mice.PloS one · 2023Article
- The etiology and pathogenesis of type 1 diabetes - A personal, non-systematic review of possible causes, and interventions.Frontiers in endocrinology · 2022Review
- "The Gluten-Free Diet and Its Relationship with Metabolic Syndrome: Dietary Friend or Foe?"Current nutrition reports · 2021Review
- Gluten Free Diet for the Management of Non Celiac Diseases: The Two Sides of the Coin.Healthcare (Basel, Switzerland) · 2020Review
- Characteristics and Maternal-Fetal Outcomes of Pregnant Women Without Celiac Disease Who Avoid Gluten.Digestive diseases and sciences · 2020Observational
- PPARs and the Development of Type 1 Diabetes.PPAR research · 2020Review
- The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis.Frontiers in endocrinology · 2020Review
- Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice.Diabetologia · 2019Article
- Possible Prevention of Diabetes with a Gluten-Free Diet.Nutrients · 2018Review
- Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark.BMJ (Clinical research ed.) · 2018Article
- P31-43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: a role in celiac disease.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (p < 0.0001) in the gluten-free group. The islets of Langerhans were less infiltrated (p < 0.001) and the intestinal expression of RORγt (Th17) (p < 0.0001) reduced in mice whose mothers were Gluten-free during pregnancy. Conclusion. A gluten-free diet exclusively during pregnancy efficiently prevents autoimmune diabetes development in offspring and reduces insulitis and intestinal expression of RORγt (Th17).
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