Evidence map›Paper›PMID 27642605›Full record

ArticleBioMed research international2016

Silver-Coated Hip Megaprosthesis in Oncological Limb Savage Surgery.

F Donati, G Di Giacomo, S D'Adamio, A Ziranu, S Careri, Ma Rosa, G Maccauro

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07337018 (Valutazione Resezioni Oncologiche e Ricostruzione Con Utilizzo di Impianti Protesici in Chirurgia Oncologica Ortopedica), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07337018 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Valutazione Resezioni Oncologiche e Ricostruzione Con Utilizzo di Impianti Protesici in Chirurgia Oncologica Ortopedica (Evaluation of Oncologic Resections and Reconstruction Using Prosthetic Implants in Orthopedic Oncologic Surgery)

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled100ConditionsBone Tumor
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Journal of functional biomaterials · 2023
    Article
  17. Article
  18. Blood-saving dissection with monopolar tungsten needle electrodes and Teflon-coated spatula electrodes in tumor orthopedics.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

F DonatiDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.ORCID 0000-0003-1362-8502
G Di GiacomoDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.
S D'AdamioDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.
A ZiranuDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.ORCID 0000-0002-4656-7390
S CareriDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.
Ma RosaDivision of Orthopedic and Traumatology, Messina University, Messina, Italy.
G MaccauroDivision of Orthopedic and Traumatology, Catholic University of the Sacred Heart, Rome, Italy.
Università Cattolica del Sacro Cuore · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver coating has demonstrated good antimicrobial activity and low toxicity. Silver-coated megaprostheses have been introduced in oncological musculoskeletal surgery considering the high rate of infection. We conducted a retrospective analysis on 68 cases of primary or metastatic bone tumors, affecting the proximal femur, treated between 2005 and 2016 with wide margins resection and tumor implants reconstruction. All patients were treated by the same surgeon, with antibiotic prophylaxis according to a standard protocol. In 55.9% of patients silver-coated hip hemiarthroplasty was implanted; in the remaining 44.1% uncoated megaprostheses were implanted. Patients were reevaluated recording the complications and focusing the analysis on infective complications. The average follow-up was 46.5 months. No patient has shown any sign of local or general silver toxicity. A SEM analysis was conducted on the 3-silver-coated hip hemiarthroplasty explanted confirming a severe degradation with a small amount of residual silver on the coating surface. Silver-coated hip prostheses have a lower rate of early infection than traditional implants but showed a reduction of antimicrobial activity for silver coating wear. We recommend using silver-coated prosthesis as primary implants for limb salvage surgery, in primary or metastatic bone tumors affecting the proximal femur, considering the absence of signs of toxicity and the lower rate of early infection.

Indexed as

Coated Materials, BiocompatibleHip ProsthesisSilverAdultAgedFemaleFemoral NeoplasmsFemur HeadFemur NeckFollow-Up StudiesHumansMaleMiddle AgedNeoplasm MetastasisRetrospective StudiesCoated Materials, BiocompatibleSilver

Identifiers

PMID27642605
PMCPMC5011498
OpenAlexW2511243271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.