ReviewAnesthesiology and pain medicine2016
Current Understanding on Pain Mechanism in Migraine and Cluster Headache.
Review in Anesthesiology and pain medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor.Headache · 2026Article
- Diagnostic value of combined detection of serum NLR and CRP for migraine patients in the attack stage: A prospective study.Journal of medical biochemistry · 2026Article
- Cluster headache: understandings of current knowledge and directions for whole process management.Frontiers in neurology · 2024Review
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
- Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis: A case report.World journal of clinical cases · 2022Article
- Characterization of Headache in COVID-19: a Retrospective Multicenter Study.Molecular neurobiology · 2021Observational
- Peripheral Neuromodulation for the Management of Headache.Anesthesiology and pain medicine · 2020Review
- Step-Headache: A Distinct Symptom of Migraine.Journal of neurosciences in rural practice · 2020Article
- Acute Treatment of Cluster Headache with Great Occipital Nerve Blockade.Noro psikiyatri arsivi · 2019Article
- Review
- Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Behavioral and psychological aspects of cluster headache: an overview.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Manual therapy for chronic migraine: a pragmatic randomised controlled trial study protocol.Chiropractic & manual therapies · 2019Article
- A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey.Neural regeneration research · 2019Article
- Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine.British journal of pharmacology · 2018Review
- Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.The journal of headache and pain · 2018Article
- Health Care Utilization and Direct Costs Among Patients Diagnosed with Cluster Headache in U.S. Health Care Claims Data.Journal of managed care & specialty pharmacy · 2018Observational
- Article
- Headaches in Patients with Pituitary Tumors: a Clinical Conundrum.Current pain and headache reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMigraine and cluster headache are undoubtedly painful conditions. The respective pathogenesis of these two conditions is incompletely understood. In both cases, the treatments used have largely been empirical and have relied to a much lesser extent on our understanding of the mechanisms causing pain. We hereby review the pain mechanisms in migraine and cluster headache, two of the commonest primary headache disorders. EVIDENCE ACQUISITION: A review of the English literature was conducted by searching PubMed for studies on pain mechanism in migraine and cluster headache. We entered [migraine] and [pain mechanism] in Pubmed and 488 articles were obtained. Articles were then included according to their relevance to the topic. Similarly, [cluster headache] and [pain mechanism] revealed 79 search results.
resultsThere is evidence that the trigeminovascular system and neurogenic inflammation play important roles, together with certain areas of the brain, leading to these conditions being termed 'neurovascular headaches'. Functional imaging findings suggest a possible role of the dorsolateral pons in generating migraine attacks while the role of the hypothalamus in cluster headache is more firmly established.
conclusionsMigraine and cluster headache have complex pathophysiologies. The exact mechanism causing pain in both conditions is incompletely understood and more research needs to be undertaken in this area.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.