ReviewAnesthesiology and pain medicine2016
The Role of Caffeine in Pain Management: A Brief Literature Review.
Review in Anesthesiology and pain medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials.Clinical oral investigations · 2021Pooled it
- Effect of Caffeine on the Bioavailability and Pharmacokinetics of an Acetylsalicylic Acid-Paracetamol Combination: Results of a Phase I Study.Advances in therapy · 2019Trial
- Caffeine and Headache: Exploring the Multifaceted Relationship.Brain and behavior · 2026Review
- Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health.Hereditas · 2026Review
- Dietary habits and adherence to the Mediterranean diet in a cohort of Parkinson's disease patients in Lithuania.Frontiers in nutrition · 2026Article
- Neonatal pain experience and pain sensitivity trajectories in preterm infants: A longitudinal study of flexion withdrawal reflex thresholds over the first two years of age.The journal of pain · 2025Article
- Self-Management Strategies for Treating Pediatric and Adolescent Headaches and Migraines with Over-the-Counter Molecules: Expert Opinion and Literature Review.Pain and therapy · 2025Review
- Caffeine Intake Mediates the Relationship Between Problematic Overstudying and Psychological Distress.Nutrients · 2025Article
- Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Exploring the Spectrum of Temporal Summation and Conditioned Pain Modulation Responses in Pain-Free Individuals Using a Tonic Heat Pain and Cold Pressor Test Paradigms.European journal of pain (London, England) · 2025Observational
- Conditioned pain modulation elicited through manual pressure techniques on the cervical spine: a crossover study.Pain reports · 2025Article
- Dose-Dependent Interaction Between Caffeine and Morphine in Analgesia in the Hot-Plate in Mice.Addiction & health · 2025Article
- Relationship Between Physicochemical Parameters and Risk of Analgesics and Antibiotics of Effluents From Three Selected Hospitals in Kumasi Metropolis, Ghana.TheScientificWorldJournal · 2025Article
- Exploring the association between dietary caffeine and chronic musculoskeletal pain: a cross-sectional analysis of NHANES.Frontiers in nutrition · 2025Article
- Management of Post Dural Puncture Headache During Spinal Cord Stimulation Trials: A Review of Current Literature.Current pain and headache reports · 2024Review
- Newly synthesized chitosan nanoparticles loaded with caffeine/moringa leaf extracts Halt Her2, BRCA1, and BRCA2 expressions.Scientific reports · 2024Article
- TRPA1, TRPV1, and Caffeine: Pain and Analgesia.International journal of molecular sciences · 2024Review
- Use of Prescribed and Non-Prescribed Treatments for Cluster Headache in a Swedish Cohort.Brain sciences · 2024Article
- Article
- Temporal associations between use of psychoactive substances and somatic symptoms in the daily lives of people with fibromyalgia.Pain medicine (Malden, Mass.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCaffeine is the most commonly used psychoactive legal drug in the world. Caffeine's role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control and attract investigators to this topic. EVIDENCE ACQUISITION: The data on Caffeine as an adjuvant therapy or as a main component for pain modulation has been narratively reviewed.
resultsCaffeine plays an important role in pain modulation through their action on adenosine receptors which are involved in nociception. The use of caffeine as adjuvant treatment was well-established in the literature and caffeine is currently available in some over the counter medications. Studies showed controversial results about the interaction between caffeine and morphine for pain relief in patients with terminal stage cancer. As a main component for pain modulation, Caffeine can be used for hypnic headache and postdural puncture headache.
conclusionsCaffeine has a potential role for pain modulation. Current evidence on caffeine use for migraine and terminal stage cancer is not well-established. Future studies should address the use of caffeine alone for different types of pain with dose escalation and standardization of outcome measurement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.