Evidence map›Paper›PMID 27642550›Full record

ArticleCurrent stem cell reports2016

Designing Biopolymer Microthreads for Tissue Engineering and Regenerative Medicine.

Megan P O'Brien, Meagan E Carnes, Raymond L Page, Glenn R Gaudette, George D Pins

Abstract read
In one paragraph

Article in Current stem cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Tissue Engineered 3D Constructs for Volumetric Muscle Loss.Annals of biomedical engineering · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Etching anisotropic surface topography onto fibrin microthread scaffolds for guiding myoblast alignment.Journal of biomedical materials research. Part B, Applied biomaterials · 2020
    Article
  8. Article
  9. Biomimetic Scaffolds in Skeletal Muscle Regeneration.Discoveries (Craiova, Romania) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan P O'BrienDepartment of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA, 01609.
Meagan E CarnesDepartment of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA, 01609.
Raymond L PageDepartment of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA, 01609.
Glenn R GaudetteDepartment of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA, 01609.
George D PinsDepartment of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Worcester, MA, 01609.

Funding

Biological sutures to enhance progenitor cell delivery and retention in the heartR01HL115282 · NHLBI · WORCESTER POLYTECHNIC INSTITUTE · PI GAUDETTE, GLENN R · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL115282
6 · The paper itself

Abstract

Native tissue structures possess elaborate extracellular matrix (ECM) architectures that inspire the design of fibrous structures in the field of regenerative medicine. We review the literature with respect to the successes and failures, as well as the future promise of biopolymer microthreads as scaffolds to promote endogenous and exogenous tissue regeneration. Biomimetic microthread tissue constructs have been proposed for the functional regeneration of tendon, ligament, skeletal muscle, and ventricular myocardial tissues. To date, biopolymer microthreads have demonstrated promising results as materials to recapitulate the hierarchical structure of simple and complex tissues and well as biochemical signaling cues to direct cell-mediated tissue regeneration. Biopolymer microthreads have also demonstrated exciting potential as a platform technology for the targeted delivery of stem cells and therapeutic molecules. Future studies will focus on the design of microthread-based tissue analogs that strategically integrate growth factors and progenitor cells to temporally direct cell-mediated processes that promote enhanced functional tissue regeneration.

Indexed as

biopolymercardiac tissue regenerationMicrothreadsmusculoskeletal tissue regenerationtargeted stem cell delivery

Identifiers

PMID27642550
PMCPMC5019572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.