Evidence map›Paper›PMID 27642543›Full record

ArticleCurrent pediatrics reports2013

Genes, Exomes, Genomes, Copy Number: What is Their Future in Pediatric Renal Disease.

Matthew G Sampson, Harald Jüppner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current pediatrics reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew G SampsonDivision of Pediatric Nephrology, Department of Pediatrics and Communicable Disease, University of Michigan School of Medicine, West Medical Center Drive, A510D MSRB1, Ann Arbor, MI 48109, USA.
Harald JüppnerPediatric Nephrology and Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Thier 10, Boston, MA 02114, USA.

Funding

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Training Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KRETZLER, MATTHIAS · 2009 to 2023
$20.3M
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C · 2008 to 2022
$12.9M
CLINICAL RESEARCH TRAINING IN KIDNEY DISEASET32DK007785 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2000 to 2019
$3.9M
An Integrative Systems Genetics Approach to Nephrotic SyndromeK08DK100662 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMPSON, MATTHEW GORDON · 2013 to 2015
$460k
NCATS NIH HHS UL1 TR000433NCRR NIH HHS UL1 RR024986NIDDK NIH HHS K08 DK100662NIDDK NIH HHS P30 DK081943NIDDK NIH HHS U54 DK083912
6 · The paper itself

Abstract

The influence of genetic variation on the pathogenesis of pediatric kidney disease extends from the earliest stages of kidney development in utero to conditions arising throughout a child's life. Major advances in genomic technologies, computing power, and bioinformatics analyses have resulted in the accelerated discovery of novel genes and risk loci associated with both inherited and sporadic forms of pediatric kidney disease. In this review, we will highlight studies over the past year that used diverse approaches to discover novel genes and loci associated with pediatric renal disease. We will also discuss reports that investigate the association with disease of previously discovered risk variants in novel populations, different phenotypes, or in model systems. Finally, we will discuss how we believe genomic inquiry will evolve in pediatric kidney disease in the future. Together, these studies illustrate that almost every child with a kidney condition could participate in some form of genomic investigation.

Indexed as

Chronic kidney diseaseCNVExomeFamily studiesGenesGenomeGenomicsGWASNephrotic syndromeNext-generation sequencingPediatric nephrologyPhenotypingSingle nucleotide variantTranscriptome

Identifiers

PMID27642543
PMCPMC5022771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.