Evidence map›Paper›PMID 27642386›Full record

ArticleThe Pan African medical journal2016

[Incidence of strokes in HIV-positive patients treated with long term antiretroviral treatment].

Yacouba Njankouo Mapoure, Ines Nepetsoun Nkongni, Henry Namme Luma, Bertrand Hugo Mbtachou Ngahane, Esther Barla, Samuel Ngwane, Albert Soné Mouelle, Alfred Kongnyu Njamnshi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yacouba Njankouo MapoureFaculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Hôpital Général de Douala, Cameroun.
Ines Nepetsoun NkongniFaculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Hôpital Général de Douala, Cameroun.
Henry Namme LumaService d'Hépato-gastro-entérologie, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, Cameroun.
Bertrand Hugo Mbtachou NgahaneService de Pneumologie, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Hôpital Général de Douala, Cameroun.
Esther BarlaService de Pédiatrie, Centre de Traitement Agréé de l'Hôpital Général de Douala, Cameroun.
Samuel NgwaneService de Dermatologie, Hôpital Général de Douala, Cameroun.
Albert Soné MouelleDépartement des Sciences Cliniques, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Cameroun.
Alfred Kongnyu NjamnshiDépartement de Neurologie, Hôpital Central de Yaoundé, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, Cameroun.
University of Douala · CMCentral Hospital of Yaoundé · CMUniversité de Yaoundé I · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith the introduction of triple therapy regimen in 1996, the morbidity and mortality associated with HIV infection decreased significantly. Concomitantly with this clinical success, several metabolic changes including diabetes, arterial hypertension, dyslipidemia and lipodystrophy were observed, being associated with the risk of stroke. This study aims to determine the incidence of strokes in HIV-positive patients treated with long term antiretroviral treatment.

methodsThis was a retrospective cohort study of HIV-positive adult patients receiving long term antiretroviral treatment for at least 12 months. It was conducted at the Approved Treatment Centres of Douala General Hospital (HGD); data collection spanned a 10-year period from May 2001 to April 2010. Patients were treated according to Cameroon national treatment guidelines. The Kaplan-Meyer method was used to determine the time of stroke onset. The Khi-2 test was used to investigate the association between two qualitative variables. The statistical significance level was set at 0.05.

results407 patients were included in the study, 62.4% were female, the average age was 40.1 ± 9.9 years. The incidence of strokes was 1.7% over 72 months follow up with no significant difference between women and men (P = 0.76). The incidence rate was calculated to be 0.3 per 100 person years. 85.7% of cases had an ischemic stroke. The mean time from stroke onset was 33.4 months. Factors associated with stroke occurrence were: patients who underwent treatment at WHO Clinical Stage III and IV and with CD4 count> 100/mm3at the start of antiretroviral therapy.

conclusionThe incidence of stroke in HIV-positive patients treated with long term antiretroviral therapy is similar to that previously reported but these strokes occur at an early age and justify increased clinical monitoring. A prospective study involving a control population is needed.

Indexed as

AdultAge FactorsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCameroonCD4 Lymphocyte CountFemaleFollow-Up StudiesHIV InfectionsHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesStrokeAnti-HIV Agentsantiretroviral triple therapy regimenCameroonHIV infectionStrokes

Identifiers

PMID27642386
PMCPMC5012720
OpenAlexW2378294443

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.