ArticleNature physics2016
Self-Driven Jamming in Growing Microbial Populations.
Article in Nature physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- 3D confinement physically regulates cell cycle progression in budding yeast.Nature communications · 2026Article
- Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up.Nature communications · 2026Article
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Biophysical metabolic modeling of complex bacterial colony morphology.Cell systems · 2025Article
- Mechanics control the proliferation of diatoms entrapped in hydrogels.Soft matter · 2025Article
- Colony pattern multistability emerges from a bistable switch.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Disentangling the feedback loops driving spatial patterning in microbial communities.NPJ biofilms and microbiomes · 2025Review
- Growing bacterial colonies harness emergent genealogical demixing to regulate organizational entropy.Biophysical reports · 2024Article
- Formations of force network and softening of amorphous elastic materials from a coarsen-grained particle model.Scientific reports · 2024Article
- Interplay between environmental yielding and dynamic forcing modulates bacterial growth.Biophysical journal · 2024Article
- Article
- Intracellular dry mass density increases under growth-induced pressure.Open research Europe · 2024Article
- Spatial constraints and stochastic seeding subvert microbial arms race.PLoS computational biology · 2024Article
- Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.Soft matter · 2023Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Impact of crowding on the diversity of expanding populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Adhesion strength between cells regulate nonmonotonic growth by a biomechanical feedback mechanism.Biophysical journal · 2022Article
- Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids.Nature communications · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In natural settings, microbes tend to grow in dense populations [1-4] where they need to push against their surroundings to accommodate space for new cells. The associated contact forces play a critical role in a variety of population-level processes, including biofilm formation [5-7], the colonization of porous media [8, 9], and the invasion of biological tissues [10-12]. Although mechanical forces have been characterized at the single cell level [13-16], it remains elusive how collective pushing forces result from the combination of single cell forces. Here, we reveal a collective mechanism of confinement, which we call self-driven jamming, that promotes the build-up of large mechanical pressures in microbial populations. Microfluidic experiments on budding yeast populations in space-limited environments show that self-driven jamming arises from the gradual formation and sudden collapse of force chains driven by microbial proliferation, extending the framework of driven granular matter [17-20]. The resulting contact pressures can become large enough to slow down cell growth, to delay the cell cycle in the G1 phase, and to strain or even destroy the microenvironment through crack propagation. Our results suggest that self-driven jamming and build-up of large mechanical pressures is a natural tendency of microbes growing in confined spaces, contributing to microbial pathogenesis and biofouling [21-26].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.