Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats.

Esrafil Mansouri, Ameneh Hardani, Mohamad Reza Afzalzadeh, Ashraf Amir Zargar, Zakiaeh Meamar

Open access · greenAbstract read

In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

Phytochemical Profile, Antioxidant Potential, Antimicrobial Activity, and Cytotoxicity of Dry Extract fromMolecules (Basel, Switzerland) · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Esrafil MansouriDepartment of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran.

Ameneh HardaniDepartment of Public Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences, Iran.

Mohamad Reza AfzalzadehDepartment of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.

Ashraf Amir ZargarDepartment of Physiology and Diabetes Research Center, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Iran.

Zakiaeh MeamarDepartment of Engineering Environmental Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ahvaz Jundishapur University of Medical Sciences · IRShahid Chamran University of Ahvaz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The present study was designed to assess the combined effects of retinoic acid and Rosa damascena mill on wound in diabetic rats. Seventy-two rats were used in this study. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg. Kg(-1)). Then, a full thickness wound was created on dorsal surface of all animals. After that, rats were divided, into three groups; control (normal saline), positive control (Phenytoin), and case (combined of 0.1% Tretinoein lotion and hydro-alcoholic extract of Rosa damascena mill). Afterward, wounds were evaluated macroscopically and microscopically on days 5, 10 and 15. Macroscopic and microscopic evaluations showed a significant improvement (p<0.05) of wounds in case group on 5(th) and 10(th) days when compared to positive control and control groups. The combination of Retinoic acid and hydro-alcholic extract of Rosa damascena mill can accelerate wound healing in diabetic rats.

Indexed as

Diabetic ulcerRetinoic acidRosa damascene

Identifiers

PMID27642329

PMCPMC5018286

OpenAlexW2291447961

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.