Observational studyJournal of the American Geriatrics Society2017
Changes in Medication Use After Dementia Diagnosis in an Observational Cohort of Individuals with Diabetes Mellitus.
Observational study in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Prescribing trends and time series analysis of blood pressure-lowering drugs among patients with dementia: a multinational database study.EClinicalMedicine · 2025Article
- Medications use among women with dementia: a cohort study.Aging clinical and experimental research · 2022Article
- Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease.BMC geriatrics · 2021Article
- Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years.Journal of Alzheimer's disease : JAD · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesTo assess changes in medication use after a diagnosis of dementia in individuals with type 2 diabetes mellitus.
designDifference-in-differences analysis of changes in the number of dispensed chronic medications between individuals with and without newly diagnosed dementia.
settingIntegrated healthcare delivery system, Kaiser Permanente Northern California.
participantsIndividuals aged 50 and older without prevalent dementia with type 2 diabetes mellitus enrolled in a baseline survey. During 5 years of follow-up, 193 individuals with a new diagnosis of dementia were identified, and risk-set sampling was used to randomly select five reference subjects per case matched on 5-year age categories and sex (965 matched participants), resulting in an analytical sample of 1,158. MEASUREMENTS: The exposure was new diagnosis of dementia. The primary outcome was change in number of current chronic medications (total, cardiovascular (blood pressure and lipid control), diabetes mellitus) at three times: 1 year before index date (preindex date), date of diagnosis of dementia or matched reference date (index date), and up to 1 year after index date or end of follow-up if censored before 1 year (postindex date).
resultsAfter adjustment, the number of chronic medications and the subset of cardiovascular medications declined after a dementia diagnosis in the overall cohort and in age-, sex-, and time-matched reference individuals, but the decline was significantly greater in the group with dementia (0.71 medications fewer than the reference group, P = .02). The number of diabetes mellitus medications declined in both groups, but the declines were not statistically different (0.18 medications fewer than the reference group, P = .008).
conclusionsUse of cardiometabolic medications fell after a diagnosis of dementia, as recommended in national guidelines.
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