Evidence map›Paper›PMID 27642011›Full record

ArticleeLife2016

Regulation of X-linked gene expression during early mouse development by

Feng Wang, JongDae Shin, Jeremy M Shea, Jun Yu, Ana Bošković, Meg Byron, Xiaochun Zhu, Alex K Shalek, Aviv Regev, Jeanne B Lawrence and 4 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome research · 2025
    Article
  4. Article
  5. Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Knockout ofAnimals : an open access journal from MDPI · 2023
    Article
  13. Article
  14. The role of lncRNAs andFrontiers in cell and developmental biology · 2022
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Feng WangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
JongDae ShinDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
Jeremy M SheaDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
Jun YuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
Ana BoškovićDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
Meg ByronDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, United States.
Xiaochun ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
Alex K ShalekDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.
Aviv RegevBroad Institute of MIT and Harvard, Cambridge, United States.
Jeanne B LawrenceDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, United States.
Eduardo M TorresDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
Lihua J ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.
Oliver J RandoDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
Ingolf BachDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-4505-8946
University of Massachusetts Chan Medical School · USBroad Institute · USHarvard University · USKonyang University · KR

Funding

PILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6M
Dietary effects on the sperm epigenomeR01HD080224 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANDO, OLIVER J · 2014 to 2022
$5.9M
RNA and Genomic Junk in Fundamental Chromosome Architecture and RegulationR35GM122597 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEANNE Bentley LAWRENCE · 2017 to 2026
$5.3M
XIST RNA: A Key to Understand Epigenome Regulation and Chromosome StructureR01GM053234 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAWRENCE, JEANNE BENTLEY · 1996 to 2017
$5.1M
tRNA fragments as transgenerational information carriersDP1ES025458 · NIEHS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANDO, OLIVER J · 2014 to 2018
$4.2M
Roles of LIM cofactors for regulating ERalpha during oncogenesis and developmentR01CA131158 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BACH, INGOLF M · 2008 to 2017
$3.3M
NCI NIH HHS R01 CA131158NICHD NIH HHS R01 HD080224NIDDK NIH HHS P30 DK032520NIEHS NIH HHS DP1 ES025458NIGMS NIH HHS R01 GM053234NIGMS NIH HHS R35 GM122597
6 · The paper itself

Abstract

Mammalian X-linked gene expression is highly regulated as female cells contain two and male one X chromosome (X). To adjust the X gene dosage between genders, female mouse preimplantation embryos undergo an imprinted form of X chromosome inactivation (iXCI) that requires both

Indexed as

Gene Expression Regulation, DevelopmentalGenes, X-LinkedAnimalsMiceRNA, Long NoncodingSequence Analysis, RNAUbiquitin-Protein LigasesX Chromosome InactivationRlim protein, mouseRNA, Long NoncodingUbiquitin-Protein LigasesXIST non-coding RNAdevelopmental biologymousemouse preimplantation developmentRlim/Rnf12single embryo RNA-seqstem cellsX chromosome inactivationXistX upregulation

Identifiers

PMID27642011
PMCPMC5059138
OpenAlexW2523034138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.