Evidence map›Paper›PMID 27641724›Full record

ReviewStem cells (Dayton, Ohio)2017

Concise Review: Organ Engineering: Design, Technology, and Integration.

Gaurav Kaushik, Jeroen Leijten, Ali Khademhosseini

Abstract readReview
In one paragraph

Review in Stem cells (Dayton, Ohio), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Extrusion bioprinting: meeting the promise of human tissue biofabrication?Progress in biomedical engineering (Bristol, England) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Microphysiological Systems: Design, Fabrication, and Applications.ACS biomaterials science & engineering · 2020
    Article
  12. Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.Small (Weinheim an der Bergstrasse, Germany) · 2019
    Review
  13. Article
  14. Review
  15. 3D Bioprinting in Skeletal Muscle Tissue Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2019
    Review
  16. Article
  17. Article
  18. Article
  19. Spatially and Temporally Controlled Hydrogels for Tissue Engineering.Materials science & engineering. R, Reports : a review journal · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gaurav KaushikHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-8461-1647
Jeroen LeijtenHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ali KhademhosseiniHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Organ Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5M
3D combinatorial microenvironments for effective cell based therapyR01HL099073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, LIAO, RONGLIH · 2010 to 2013
$2.6M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
A Microfabrication Platform for Direct Printing Vascularized Functional Tissue CoR01EB012597 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2010 to 2013
$1.4M
Microengineered Osteoinductive and Vasculogenic ScaffoldR56AR063745 · NIAMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JABBARI, ESMAIEL · 2013 to 2014
$669k
A miniaturized model of human skin and lymph node for drug discovery and testingR56AI105024 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2014 to 2014
$442k
NHLBI NIH HHS R01 HL099073NIAID NIH HHS R56 AI105024NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R56 AR063745NIBIB NIH HHS R01 EB012597NIBIB NIH HHS T32 EB016652NIDCR NIH HHS R01 DE021468
6 · The paper itself

Abstract

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed. Stem Cells 2017;35:51-60.

Indexed as

TechnologyAnimalsHumansSignal TransductionTissue EngineeringTissue ScaffoldsDevelopmental biologyMicrofluidicsOrgan engineeringThree-dimensional printingTissue engineering

Identifiers

PMID27641724
PMCPMC6527109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.