ArticleScientific reports2016
Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of 10 years of unpredictable chronic stress in zebrafish.Lab animal · 2023Pooled it
- Psychobiotic interventions for anxiety in young people: a systematic review and meta-analysis, with youth consultation.Translational psychiatry · 2021Pooled it
- Oral Administration of Lactiplantibacillus plantarum KBL396 Regulates Serum 5-Hydroxytryptamine and Gut Microbiota: Evidence from a Preclinical Mouse Model and a Randomized Controlled Human Trial.Probiotics and antimicrobial proteins · 2026Trial
- Trial
- Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.Biomedicines · 2026Review
- The Role of ProbioticsInternational journal of molecular sciences · 2026Review
- Marginal link between sociality and gut microbiome in disparate mammalian hosts.FEMS microbes · 2026Article
- Assessment of Probiotics' Impact on Neurodevelopmental and Behavioral Responses in Zebrafish Models: Implications for Autism Spectrum Disorder Therapy.Probiotics and antimicrobial proteins · 2025Article
- Microbiota-gut-brain axis in avian parenting: gut microbiome associates with nest-construction behavior and neural gene expression in a songbird.Animal microbiome · 2025Article
- Psychobiotics in Aquaculture: Harnessing the Microbiome-Gut-Brain Axis for Stress Management and Production Enhancement in Fish.Animals : an open access journal from MDPI · 2025Review
- Interplay between antipredator behavior, parasitism, and gut microbiome in wild stickleback populations.NPJ biofilms and microbiomes · 2025Article
- Potential Role of Probiotic StrainBiology · 2025Article
- Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model.Pflugers Archiv : European journal of physiology · 2025Article
- Gut microbiota diversity affects fish behaviour and is influenced by host genetics and early rearing conditions.Open biology · 2025Article
- Role of Lactobacillus plantarum-Derived Extracellular Vesicles in Regulating Alcohol Consumption.Molecular neurobiology · 2025Article
- Microbiota-Gut-Brain Axis: Mass-Spectrometry-Based Metabolomics in the Study of Microbiome Mediators-Stress Relationship.Biomolecules · 2025Review
- Refinement of the novel tank diving test: toward standardized and robust analysis of anxiety-like behavior in zebrafish.Frontiers in behavioral neuroscience · 2025Article
- Green Tea Attenuates the Particulate Matter (PM)Journal of microbiology and biotechnology · 2024Article
- High-quality draft genome ofMicrobiology resource announcements · 2024Article
- Zebrafish (Ecology and evolution · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The consumption of probiotics has become increasingly popular as a means to try to improve health and well-being. Not only are probiotics considered beneficial to digestive health, but increasing evidence suggests direct and indirect interactions between gut microbiota (GM) and the central nervous system (CNS). Here, adult zebrafish were supplemented with Lactobacillus plantarum to determine the effects of probiotic treatment on structural and functional changes of the GM, as well as host neurological and behavioral changes. L. plantarum administration altered the β-diversity of the GM while leaving the major core architecture intact. These minor structural changes were accompanied by significant enrichment of several predicted metabolic pathways. In addition to GM modifications, L. plantarum treatment also significantly reduced anxiety-related behavior and altered GABAergic and serotonergic signaling in the brain. Lastly, L. plantarum supplementation provided protection against stress-induced dysbiosis of the GM. These results underscore the influence commensal microbes have on physiological function in the host, and demonstrate bidirectional communication between the GM and the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.