Evidence map›Paper›PMID 27641628›Full record

ArticleToxicology and applied pharmacology2016

A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways.

Shinji Furuya, Grace A Chappell, Yasuhiro Iwata, Takeki Uehara, Yuki Kato, Hiroshi Kono, Ramon Bataller, Ivan Rusyn

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. The Link between Alcohol Consumption and Kidney Injury.The American journal of pathology · 2026
    Review
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  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Shinji FuruyaDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Grace A ChappellDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Yasuhiro IwataDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Takeki UeharaLaboratory of Veterinary Pathology, Osaka Prefecture University, Osaka, Japan.
Yuki KatoLaboratory of Veterinary Pathology, Osaka Prefecture University, Osaka, Japan.
Hiroshi KonoFirst Department of Surgery, University of Yamanashi, Yamanashi, Japan.
Ramon BatallerDivision of Gastroenterology & Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Ivan RusynDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address: irusyn@tamu.edu.
Texas A&M University · USOsaka Prefecture University · JPUniversity of North Carolina at Chapel Hill · USUniversity of Yamanashi · JP

Funding

Molecular Subtypes for Targeted Therapies in Alcoholic HepatitisU01AA021908 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATALLER, RAMON · 2013 to 2017
$6.0M
NIAAA NIH HHS U01 AA021908
6 · The paper itself

Abstract

Clinical data strongly indicate that acute kidney injury (AKI) is a critical complication in alcoholic hepatitis, an acute-on-chronic form of liver failure in patients with advanced alcoholic fibrosis. Development of targeted therapies for AKI in this setting is hampered by the lack of an animal model. To enable research into molecular drivers and novel therapies for fibrosis- and alcohol-associated AKI, we aimed to combine carbon tetrachloride (CCl

Indexed as

Disease Models, AnimalAcute Kidney InjuryAnimalsEthanolLiver CirrhosisMaleMiceMice, Inbred C57BLEthanol

Identifiers

PMID27641628
PMCPMC5323078
OpenAlexW2519158199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.