Evidence map›Paper›PMID 27641493›Full record

ArticleNeuron2016

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.

Jin Cheng, Sadhna Sahani, Torben Johann Hausrat, Jenq-Wei Yang, Haichao Ji, Nikolai Schmarowski, Heiko Endle, Xinfeng Liu, Yunbo Li, Rahel Böttche and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Lysophospholipid receptors in neurodegeneration and neuroprotection.Exploration of neuroprotective therapy · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 4 countries.

Jin ChengInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Sadhna SahaniInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Torben Johann HausratUniversity Medical Center Hamburg-Eppendorf, Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg (ZMNH), 20251 Hamburg, Germany.
Jenq-Wei YangInstitute of Physiology, University Medical Center, Johannes Gutenberg University, 55128 Mainz, Germany.
Haichao JiInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Nikolai SchmarowskiInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Heiko EndleInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Xinfeng LiuInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Yunbo LiInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Rahel BöttcheInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Konstantin RadyushkinFocus Program Translational Neuroscience, Johannes Gutenberg University, 55128 Mainz, Germany.
Hans M MaricDepartment of Drug Design and Pharmacology, Center for Biopharmaceuticals, University of Copenhagen, 2100 Copenhagen, Denmark.
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
Zoltán MolnárDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK.
Pierre-Hugues ProuvotInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Thorsten TrimbuchInstitute for Cell Biology and Neurobiology, Charité, 10117 Berlin, Germany.
Olaf NinnemannInstitute for Cell Biology and Neurobiology, Charité, 10117 Berlin, Germany.
Jisen HuaiInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Wei FanInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Barbara VisentinLpath Inc., San Diego, CA 92121, USA.
Roger SabbadiniLpath Inc., San Diego, CA 92121, USA.
Kristian StrømgaardDepartment of Drug Design and Pharmacology, Center for Biopharmaceuticals, University of Copenhagen, 2100 Copenhagen, Denmark.
Albrecht StrohInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Heiko J LuhmannInstitute of Physiology, University Medical Center, Johannes Gutenberg University, 55128 Mainz, Germany.
Matthias KneusselUniversity Medical Center Hamburg-Eppendorf, Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg (ZMNH), 20251 Hamburg, Germany.
Robert NitschInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany. Electronic address: robert.nitsch@unimedizin-mainz.de.
Johannes VogtInstitute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany. Electronic address: johannes.vogt@unimedizin-mainz.de.
University Medical Center of the Johannes Gutenberg University Mainz · DEJohannes Gutenberg University Mainz · DECharité - Universitätsmedizin Berlin · DELpath (United States) · USUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Copenhagen · DKUniversity of Oxford · GB

Funding

Medical Research Council G0700377Medical Research Council MC_PC_15102Medical Research Council MR/N026039/1
6 · The paper itself

Abstract

Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both in PRG-2 full knockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2-deficient thalamocortical fibers. PRG-2 electroporation in the PRG-2

Indexed as

AnimalsAxon GuidanceCerebral CortexCytoskeletal ProteinsDiscrimination, PsychologicalGrowth ConesLysophospholipidsMembrane ProteinsMiceMice, KnockoutNeural PathwaysPhosphorylationSignal TransductionThalamusCytoskeletal Proteinslysophosphatidic acidLysophospholipidsMembrane ProteinsPrg-2 protein, mouseradixin

Identifiers

PMID27641493
PMCPMC5065528
OpenAlexW2519434201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.