ArticleScientific reports2016
Physicochemistry and cardiovascular toxicity of metal fume PM2.5: a study of human coronary artery endothelial cells and welding workers.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current state of knowledge on the health effects of engineered nanomaterials in workers: a systematic review of human studies and epidemiological investigations.Scandinavian journal of work, environment & health · 2019Pooled it
- Detection of Metal-Containing Particles in FDA-Authorized and New Disposable Electronic Cigarette Aerosols.Environmental science & technology · 2025Article
- The potential adverse human health effects of metal-containing nanoparticles: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Effect modification by cardiovascular and metabolic disease onset on long-term PMScientific reports · 2025Article
- Cardiovascular Emergency Hospitalization Risks of PMEnvironment & health (Washington, D.C.) · 2025Article
- Longitudinal changes in cardiovascular disease-related proteins in welders.International archives of occupational and environmental health · 2024Article
- Effects of occupational exposure to metal fume PMInternational archives of occupational and environmental health · 2024Article
- Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study.Metabolites · 2023Article
- Modelled lung deposition and retention of welding fume particles in occupational scenarios: a comparison to doses used in vitro.Archives of toxicology · 2022Article
- Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers.Antioxidants (Basel, Switzerland) · 2022Article
- Elevated Urinary Biomarkers of Oxidative Damage in Photocopier Operators following Acute and Chronic Exposures.Nanomaterials (Basel, Switzerland) · 2022Article
- Associations between Biomarkers of Metal Exposure and Dry Eye Metrics in Shipyard Welders: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- The impact of stay-home policies during Coronavirus-19 pandemic on the chemical and toxicological characteristics of ambient PMThe Science of the total environment · 2021Article
- Effect of welding fumes on the cardiovascular system: a six-year longitudinal study.Scandinavian journal of work, environment & health · 2021Article
- The critical role of endothelial function in fine particulate matter-induced atherosclerosis.Particle and fibre toxicology · 2020Review
- Effects of mild steel welding fume particles on pulmonary epithelial inflammation and endothelial activation.Toxicology and industrial health · 2020Article
- Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine.International journal of environmental research and public health · 2019Article
- Occupational exposure to inorganic particles during pregnancy and birth outcomes: a nationwide cohort study in Sweden.BMJ open · 2019Article
- Article
- Air Pollution Particular Matter and Atherosclerosis.Acta Cardiologica Sinica · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occupational exposure to welding fumes causes a higher incidence of cardiovascular disease; however, the association remains unclear. To clarify the possible association, exposure assessment of metal fumes with an aerodynamic diameter of <2.5 μm (PM2.5) in welding and office areas was characterized in a shipyard in Taiwan. Cardiovascular toxicity caused by PM2.5 was determined in workers (in both the welding and office areas). Significant amounts of bimodal metal fume particles with count median diameters (CMDs) of 14.1~15.1 and 126.3~135.8 nm were produced in the shipyard. Metal fume PM2.5 resulted in decreased cell viability and increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin (IL)-6, and nitric oxide (NO) in human coronary artery epithelial cells (HCAECs). We recruited 118 welding workers and 45 office workers for a personal PM2.5 exposure assessment and determination of urinary levels of 8-OHdG, 8-iso-prostaglandin F2α (8-iso-PGF2α), and various metals. We observed that a 10-μg/m(3) increase in the mean PM2.5 concentration was associated with a 2.15% increase in 8-OHdG and an 8.43% increase in 8-iso-PGF2α in welding workers. Both 8-OHdG and 8-iso-PGF2α were associated with Fe and Zn in the urine. In conclusion, metal fume PM2.5 could increase the risk of cardiovascular toxicity after inhalation.
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