ArticleBehavioural brain research2017
Learning and generalization from reward and punishment in opioid addiction.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.BMC medical genetics · 2017Pooled it
- Computational mechanisms of learning and forgetting differentiate affective and substance use disorders.Molecular psychiatry · 2026Article
- Renewal and reacquisition of substance-associated relapse.Frontiers in psychology · 2026Review
- Current interpretations of the I-PACE model of behavioral addictions.Journal of behavioral addictions · 2025Review
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Perceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers.Psychological science · 2023Article
- Circuit and Cell-Specific Contributions to Decision Making Involving Risk of Explicit Punishment in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Slower Learning Rates from Negative Outcomes in Substance Use Disorder over a 1-Year Period and Their Potential Predictive Utility.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Imprecise action selection in substance use disorder: Evidence for active learning impairments when solving the explore-exploit dilemma.Drug and alcohol dependence · 2020Article
- Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task.BMC psychiatry · 2020Article
- Computational Markers of Risky Decision-making for Identification of Temporal Windows of Vulnerability to Opioid Use in a Real-world Clinical Setting.JAMA psychiatry · 2020Article
- Impaired Learning From Errors and Punishments and Maladaptive Avoidance-General Mechanisms Underlying Self-Regulation Disorders?Frontiers in psychiatry · 2020Article
- From Isolated Emotional Memories to Their Competition During Conflict.Frontiers in behavioral neuroscience · 2020Article
- Generalization of appetitive conditioned responses.Psychophysiology · 2019Article
- Learning functions in short-term cocaine users.Addictive behaviors reports · 2019Article
- Forging Neuroimaging Targets for Recovery in Opioid Use Disorder.Frontiers in psychiatry · 2019Review
- Reward and punishment-based compound cue learning and generalization in opiate dependency.Experimental brain research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
This study adapts a widely-used acquired equivalence paradigm to investigate how opioid-addicted individuals learn from positive and negative feedback, and how they generalize this learning. The opioid-addicted group consisted of 33 participants with a history of heroin dependency currently in a methadone maintenance program; the control group consisted of 32 healthy participants without a history of drug addiction. All participants performed a novel variant of the acquired equivalence task, where they learned to map some stimuli to correct outcomes in order to obtain reward, and to map other stimuli to correct outcomes in order to avoid punishment; some stimuli were implicitly "equivalent" in the sense of being paired with the same outcome. On the initial training phase, both groups performed similarly on learning to obtain reward, but as memory load grew, the control group outperformed the addicted group on learning to avoid punishment. On a subsequent testing phase, the addicted and control groups performed similarly on retention trials involving previously-trained stimulus-outcome pairs, as well as on generalization trials to assess acquired equivalence. Since prior work with acquired equivalence tasks has associated stimulus-outcome learning with the nigrostriatal dopamine system, and generalization with the hippocampal region, the current results are consistent with basal ganglia dysfunction in the opioid-addicted patients. Further, a selective deficit in learning from punishment could contribute to processes by which addicted individuals continue to pursue drug use even at the cost of negative consequences such as loss of income and the opportunity to engage in other life activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.