ArticleThe journal of pain2016
Altered Pain Perception and Fear-Learning Deficits in Subjects With Posttraumatic Stress Disorder.
Article in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- The COMPASS framework for chronic pain and posttraumatic stress disorder: navigating the transition from threat to safety through yoga.Frontiers in public health · 2026Article
- A novel finding on the sex-dependent role of BDNF and GSK-3beta in the medial prefrontal cortex in pain threshold changes in a rat model of fear conditioning with respect to the effect of extinction and the time period after conditioning.Experimental brain research · 2025Article
- Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Article
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- Prevalence and correlates of somatization in anxious individuals in a Chinese online crisis intervention during COVID-19 epidemic.Journal of affective disorders · 2020Article
- Article
- Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review.Sensors (Basel, Switzerland) · 2020Review
- The interaction between stress and chronic pain through the lens of threat learning.Neuroscience and biobehavioral reviews · 2019Review
- Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.Neuroscience · 2018Article
- The Neuropsychological Consequences of Armed Conflicts and Torture.Current neurology and neuroscience reports · 2018Review
- Sex differences in fear discrimination do not manifest as differences in conditioned inhibition.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- COMT genotype and non-recovery after a whiplash injury in a Northern European population.BMC musculoskeletal disorders · 2017Article
- Modulation of Aversive Memory by Adult Hippocampal Neurogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
There is growing evidence that fear-learning abnormalities are involved in the development of posttraumatic stress disorder (PTSD) and chronic pain. More than 50% of PTSD patients suffer from chronic pain. This study aimed to examine the role of fear-learning deficits in the link between pain perception and PTSD. We included 19 subjects with PTSD and 21 age- and sex-matched healthy control subjects in a fear-conditioning experiment. The conditioned stimulus (CS) consisted of visual signs flashed upon a screen in front of each subject. The unconditioned stimulus was either a low or high temperature impulse delivered through a thermal contact thermode on the subjects' hand. A designation of 'CS-' was assigned to CS always followed by nonpainful low-temperature stimuli; a designation of 'CS+' was given to CS that were randomly followed by either a low or a more painful high temperature. Skin conductance was used as a physiological marker of fear. In healthy control subjects, CS+ induced more fear than CS-, and a low-temperature stimulus induced less subjective pain after CS- than after CS+. PTSD subjects failed to demonstrate such adaptive conditioning. Fear ratings after CS presentation were significantly higher in the PTSD group than in the control group. There were significant interaction effects between group and the type of CS on fear and pain ratings. Fear-learning deficits are a potentially promising, specific psychopathological factor in altered pain perception associated with PTSD. Deficits in safety learning may increase fear and, consequently, pain sensations. These findings may contribute to elucidating the pathogenesis behind the highly prevalent comorbidity that exists between PTSD and pain disorders, and to developing new treatments. PERSPECTIVE: This study provides new insights into the pathogenesis of chronic pain in patients with PTSD. The findings may help to develop new treatment strategies for this highly prevalent comorbidity in PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.