ArticleScientific reports2016
Linked color imaging application for improving the endoscopic diagnosis accuracy: a pilot study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CMV Criteria in the Detection of Gastric Diseases Using Linked Color Imaging
Computer-aided Classification of Colorectal Polyp by Using Linked Colour Imaging
Application of Linked Color Imaging（LCI） in Diagnosis of Early Gastric Cancer(EGC): a Multicenter,Prospective, Randomized Controlled Study
A Prospective Randomized Study of Linked Color Imaging and Conventional White Light Imaging in Gastroscopy for the Detection of Gastric Cancer Precursors
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of linked color imaging and white light imaging for early gastric cancer and gastrointestinal metaplasia: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Diagnostic accuracy of linked colour imaging versus white light imaging for early gastric cancers: a prospective, multicentre, randomized controlled trial study.Annals of medicine · 2022Trial
- Linked Color Imaging Can Improve Detection Rate of Early Gastric Cancer in a High-Risk Population: A Multi-Center Randomized Controlled Clinical Trial.Digestive diseases and sciences · 2021Trial
- Predictability of gastric intestinal metaplasia by patchy lavender color seen on linked color imaging endoscopy.Lasers in medical science · 2019Trial
- Topical pharyngeal anesthesia provides no additional benefit to propofol sedation for esophagogastroduodenoscopy: a randomized controlled double-blinded clinical trial.Scientific reports · 2018Trial
- Article
- Optimal post-gastroscopy timing of the urea [Frontiers in medicine · 2026Article
- Characteristics of Superficial Gastric Neoplasms Detected Not by White Light Imaging but by Linked Color Imaging.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Endoscopic appearances of gastric mucosa in different endoscopic models according to H. pylori infection status.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- From Staining Techniques to Artificial Intelligence: A Review of Colorectal Polyps Characterization.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Diagnostic ability of linked color imaging in ultraslim endoscopy to identify neoplastic lesions in the upper gastrointestinal tract.Endoscopy international open · 2022Article
- Electronic chromo-endoscopy: technical details and a clinical perspective.Translational gastroenterology and hepatology · 2022Review
- Endoscopic Diagnosis for H. pylori Infection: White Light Imaging (WLI) vs. Image-Enhanced Endoscopy (IEE).Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Application of linked color imaging in the diagnosis of early gastrointestinal neoplasms and precancerous lesions: a review.Therapeutic advances in gastroenterology · 2021Article
- RGB Pixel Brightness Characteristics of Linked Color Imaging in Early Gastric Cancer: A Pilot Study.Gastroenterology research and practice · 2020Article
- Additional value of linked color imaging in colonoscopy: a retrospective study.Endoscopy international open · 2019Article
- Clinical significance and influencing factors of linked color imaging technique in real-time diagnosis of active Helicobacter pylori infection.Chinese medical journal · 2019Article
- Linked color imaging confers benefits in profilingEndoscopy international open · 2019Article
- Efficacy of linked colour imaging in magnifying chromoendoscopy with crystal violet staining: a pilot study.International journal of colorectal disease · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoscopy has been widely used in diagnosing gastrointestinal mucosal lesions. However, there are still lack of objective endoscopic criteria. Linked color imaging (LCI) is newly developed endoscopic technique which enhances color contrast. Thus, we investigated the clinical application of LCI and further analyzed pixel brightness for RGB color model. All the lesions were observed by white light endoscopy (WLE), LCI and blue laser imaging (BLI). Matlab software was used to calculate pixel brightness for red (R), green (G) and blue color (B). Of the endoscopic images for lesions, LCI had significantly higher R compared with BLI but higher G compared with WLE (all P < 0.05). R/(G + B) was significantly different among 3 techniques and qualified as a composite LCI marker. Our correlation analysis of endoscopic diagnosis with pathology revealed that LCI was quite consistent with pathological diagnosis (P = 0.000) and the color could predict certain kinds of lesions. ROC curve demonstrated at the cutoff of R/(G+B) = 0.646, the area under curve was 0.646, and the sensitivity and specificity was 0.514 and 0.773. Taken together, LCI could improve efficiency and accuracy of diagnosing gastrointestinal mucosal lesions and benefit target biopsy. R/(G + B) based on pixel brightness may be introduced as a objective criterion for evaluating endoscopic images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.