Evidence map›Paper›PMID 27640984›Full record

ReviewNature reviews. Neuroscience2016

The effects of childhood maltreatment on brain structure, function and connectivity.

Martin H Teicher, Jacqueline A Samson, Carl M Anderson, Kyoko Ohashi

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894774 (Evaluation of an Intensive Inpatient Psychotherapy Treatment for Severely and Early Traumatized Children - Clinical Pilot Study Including Multimodal Mri), which is not on this map. Cited by 802 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
802citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03894774 nacompletednot on this map

Evaluation of an Intensive Inpatient Psychotherapy Treatment for Severely and Early Traumatized Children - Clinical Pilot Study Including Multimodal Mri (MOSES)

TypeinterventionalSponsorLMU KlinikumRan2012 to 2019Enrolled57ConditionsStress Disorders, Post-TraumaticArmsIntensive in-patient psychotherapy treatment, Treatment as usual
3 · Its place in the literature

Who cites it

802 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Critical windows: timing of child maltreatment exposure and adult mental health.Child and adolescent psychiatry and mental health · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

742 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martin H TeicherDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, Massachusetts 02215, USA.
Jacqueline A SamsonDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, Massachusetts 02215, USA.
Carl M AndersonDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, Massachusetts 02215, USA.
Kyoko OhashiDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, Massachusetts 02215, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maltreatment-related childhood adversity is the leading preventable risk factor for mental illness and substance abuse. Although the association between maltreatment and psychopathology is compelling, there is a pressing need to understand how maltreatment increases the risk of psychiatric disorders. Emerging evidence suggests that maltreatment alters trajectories of brain development to affect sensory systems, network architecture and circuits involved in threat detection, emotional regulation and reward anticipation. This Review explores whether these alterations reflect toxic effects of early-life stress or potentially adaptive modifications, the relationship between psychopathology and brain changes, and the distinction between resilience, susceptibility and compensation.

Indexed as

Adaptation, PhysiologicalAdaptation, PsychologicalAnimalsBrainCausalityChildChild AbuseHumansMental DisordersModels, NeurologicalResilience, Psychological

Identifiers

PMID27640984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.