Evidence map›Paper›PMID 27640942›Full record

ArticleAmerican journal of obstetrics and gynecology2017

Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative women.

Lisa B Haddad, Kristin M Wall, C Christina Mehta, Elizabeth T Golub, Lisa Rahangdale, Mirjam-Colette Kempf, Roksana Karim, Rodney Wright, Howard Minkoff, Mardge Cohen and 4 more

Abstract read
In one paragraph

Article in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  4. HIV infection during pregnancy in the state of Rio de Janeiro, Brazil, 2021-2023.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Lisa B HaddadDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA. Electronic address: lbhadda@emory.edu.
Kristin M WallDepartment of Epidemiology, Rollins School of Public Heath, Emory University, Atlanta, GA.
C Christina MehtaDepartment of Biostatistics and Bioinformatics, Rollins School of Public Heath, Emory University, Atlanta, GA.
Elizabeth T GolubDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Heath, Baltimore, MD.
Lisa RahangdaleDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC.
Mirjam-Colette KempfDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC.
Roksana KarimDepartment of Preventative Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Rodney WrightDepartment of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY.
Howard MinkoffDepartment of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY.
Mardge CohenDepartments of Medicine, John H. Stroger Jr. Hospital of Cook County and Rush University, Chicago, IL.
Seble KassayeDepartment of Medicine, Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine, Washington DC.
Deborah CohanDepartment of Obstetrics and Gynecology, University of California San Francisco School of Medicine, San Francisco, CA.
Igho OfotokunDepartment of Medicine, Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA.
Susan E CohnDepartment of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL.
Emory University · USUniversity of North Carolina at Chapel Hill · USAlbert Einstein College of Medicine · USGeorgetown University · USJohn H. Stroger, Jr. Hospital of Cook County · USJohns Hopkins University · USMaimonides Medical Center · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
UNC MACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146194 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Bradley Drummond, Michelle Floris-Moore · 2019 to 2026
$23.2M
Emory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NHLBI NIH HHS U01 HL146194NIAID NIH HHS P30 AI050410NIAID NIH HHS R38 AI140299NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIA NIH HHS U54 AG062334NICHD NIH HHS K23 HD078153NICHD NIH HHS U01 HD032632
6 · The paper itself

Abstract

backgroundLittle is known about fertility choices and pregnancy outcome rates among HIV-infected women in the current combination antiretroviral treatment era.

objectiveWe sought to describe trends and factors associated with live-birth and abortion rates among HIV-positive and high-risk HIV-negative women enrolled in the Women's Interagency HIV Study in the United States. STUDY

designWe analyzed longitudinal data collected from Oct. 1, 1994, through Sept. 30, 2012, through the Women's Interagency HIV Study. Age-adjusted rates per 100 person-years live births and induced abortions were calculated by HIV serostatus over 4 time periods. Poisson mixed effects models containing variables associated with live births and abortions in bivariable analyses (P < .05) generated adjusted incidence rate ratios and 95% confidence intervals.

resultsThere were 1356 pregnancies among 2414 women. Among HIV-positive women, age-adjusted rates of live birth increased from 1994 through 1997 to 2006 through 2012 (2.85-7.27/100 person-years, P trend < .0001). Age-adjusted rates of abortion in HIV-positive women remained stable over these time periods (4.03-4.29/100 person-years, P trend = .09). Significantly lower live-birth rates occurred among HIV-positive compared to HIV-negative women in 1994 through 1997 and 1997 through 2001, however rates were similar during 2002 through 2005 and 2006 through 2012. Higher CD4

conclusionUnlike earlier periods (pre-2001) when live-birth rates were lower among HIV-positive women, rates are now similar to HIV-negative women, potentially due to improved health status and combination antiretroviral treatment. Abortion rates remain unchanged, illuminating a need to improve contraceptive services.

Indexed as

Abortion, InducedAdultAntiretroviral Therapy, Highly ActiveBirth RateCase-Control StudiesCohort StudiesFemaleHIV InfectionsHumansLive BirthLongitudinal StudiesPregnancyProspective StudiesRiskYoung Adultabortionantiretroviral therapyHIVlive birthpregnancy

Identifiers

PMID27640942
PMCPMC5182149
OpenAlexW2518706949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.