Observational studyBritish journal of clinical pharmacology2016
Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study.
Observational study in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.European journal of clinical pharmacology · 2022Pooled it
- Drug-related deaths among inpatients: a meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Mortality among patients due to adverse drug reactions that lead to hospitalization: a meta-analysis.European journal of clinical pharmacology · 2018Pooled it
- Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population.PharmacoEconomics · 2026Article
- Use of medications with pharmacogenomic guidelines and adverse outcomes in hospitalised older patients: a retrospective cross-sectional study.The pharmacogenomics journal · 2026Article
- Evaluation of Adverse Drug Reactions at Hospital Besut: A 5-year Retrospective Study.Journal of research in pharmacy practice · 2026Article
- Targeted adaptive sampling enables clinical pharmacogenomics testing and genome-wide genotyping.Scientific reports · 2025Article
- A review on adverse drug reaction related to medication in health sector: an account of what we have discovered and implemented-pharmacovigilance.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Pharmacists' Experiences on Adverse Drug Reactions in Saudi Arabia: A Cross-Sectional Study.Pharmacy (Basel, Switzerland) · 2025Article
- Evaluation of a self-screening tool and patient alert cards to help patients identify and manage severe adverse drug reactions.International journal of clinical pharmacy · 2025Article
- A feasibility study on implementing pre-emptive pharmacogenomics testing in outpatient clinics in Singapore (IMPT study).The pharmacogenomics journal · 2025Article
- Real-World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review.Clinical and translational science · 2025Article
- Application of global trigger tool to determine the prevalence of adverse drug reactions in adult patients admitted to general and COVID-19 intensive care units.Frontiers in pharmacology · 2025Article
- A Retrospective Observational Study of Adverse Drug Reactions (ADR) Reported to ADR Monitoring Centre from 2010 to 2020.Current drug safety · 2025Observational
- Improving prescribing: a feasibility study of pharmacogenetic testing with clinical decision support in primary healthcare in Singapore.Family practice · 2024Article
- A review of real-world evidence on preemptive pharmacogenomic testing for preventing adverse drug reactions: a reality for future health care.The pharmacogenomics journal · 2024Review
- Medication review and deprescribing in different healthcare settings: a position statement from an Italian scientific consortium.Aging clinical and experimental research · 2024Review
- Development and validation of a pharmacogenomics reporting workflow based on the illumina global screening array chip.Frontiers in pharmacology · 2024Article
- Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors.Frontiers in medicine · 2024Review
- Incidence and Severity of Adverse Drug Reactions in Medical Intensive Care Unit.Current drug safety · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAdverse drug reactions (ADRs) contribute to poorer patient outcomes and additional burden to the healthcare system. However, data on the true burden, relevant types and drugs causing ADRs are lacking. The aim of this study was to determine the prevalence of ADR-related hospitalization in the general adult population in Singapore and to investigate their characteristics.
methodsWe prospectively recruited 1000 adult patients with unplanned admission to a large tertiary-care hospital. Two independent reviewers evaluated all suspected ADRs for causality, type, severity and avoidability. The prevalence of ADR-related hospitalization was calculated based on 'definite' and 'probable' ADRs. Logistic regression was used to evaluate predictors for having an ADR at admission.
resultsThe prevalence of all ADRs at admission was 12.4% (95% CI: 10.5-14.6%) and ADRs causing admission was 8.1% (95% CI: 6.5-10.0%). The most common ADRs were gastrointestinal-related. The most common drug category causing ADRs were cardiovascular drugs. Patients with ADRs had a longer length of stay than those who did not (median 4 vs. 3 days, P = 1.70 × 10
conclusionsWe have quantified the burden and characteristics of clinically impactful ADRs in the Singaporean general adult population. Our results will provide vital information for efforts in reducing ADRs through targeted vigilance, patient education and pharmacogenomics in Singapore.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.