ArticleScientific reports2016
Synchrotron microbeam irradiation induces neutrophil infiltration, thrombocyte attachment and selective vascular damage in vivo.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Spatially fractionated minibeam radiation delivered at clinically feasible dose rates induces transient vascular permeability.Scientific reports · 2025Article
- MRT-boost as the last fraction may be the most efficient irradiation schedule for increased survival times in a rat glioma model.Journal of synchrotron radiation · 2023Article
- Targeted Accumulation of Macrophages Induced by Microbeam Irradiation in a Tissue-Dependent Manner.Biomedicines · 2022Article
- Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy.International journal of molecular sciences · 2022Review
- Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy.Pharmaceutics · 2022Review
- Article
- Microbeam Radiotherapy-A Novel Therapeutic Approach to Overcome Radioresistance and Enhance Anti-Tumour Response in Melanoma.International journal of molecular sciences · 2021Review
- Quantification of Differential Response of Tumour and Normal Cells to Microbeam Radiation in the Absence of FLASH Effects.Cancers · 2021Article
- Transient and Efficient Vascular Permeability Window for Adjuvant Drug Delivery Triggered by Microbeam Radiation.Cancers · 2021Article
- Complete Remission of Mouse Melanoma after Temporally Fractionated Microbeam Radiotherapy.Cancers · 2020Article
- Article
- Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron.Scientific reports · 2019Article
- High spatial resolution scintillator dosimetry of synchrotron microbeams.Scientific reports · 2019Article
- Iodine nanoparticles enhance radiotherapy of intracerebral human glioma in mice and increase efficacy of chemotherapy.Scientific reports · 2019Article
- Microbeam radiation therapy - grid therapy and beyond: a clinical perspective.The British journal of radiology · 2017Review
- Computational modelling of the cerebral cortical microvasculature: effect of x-ray microbeams versus broad beam irradiation.Physics in medicine and biology · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our goal was the visualizing the vascular damage and acute inflammatory response to micro- and minibeam irradiation in vivo. Microbeam (MRT) and minibeam radiation therapies (MBRT) are tumor treatment approaches of potential clinical relevance, both consisting of parallel X-ray beams and allowing the delivery of thousands of Grays within tumors. We compared the effects of microbeams (25-100 μm wide) and minibeams (200-800 μm wide) on vasculature, inflammation and surrounding tissue changes during zebrafish caudal fin regeneration in vivo. Microbeam irradiation triggered an acute inflammatory response restricted to the regenerating tissue. Six hours post irradiation (6 hpi), it was infiltrated by neutrophils and fli1a(+) thrombocytes adhered to the cell wall locally in the beam path. The mature tissue was not affected by microbeam irradiation. In contrast, minibeam irradiation efficiently damaged the immature tissue at 6 hpi and damaged both the mature and immature tissue at 48 hpi. We demonstrate that vascular damage, inflammatory processes and cellular toxicity depend on the beam width and the stage of tissue maturation. Minibeam irradiation did not differentiate between mature and immature tissue. In contrast, all irradiation-induced effects of the microbeams were restricted to the rapidly growing immature tissue, indicating that microbeam irradiation could be a promising tumor treatment tool.
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