ReviewCurrent neuropharmacology2016
Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression.
Review in Current neuropharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07533669 (The Effect of a Sensory Modulation Room Applied in the Preoperative Period on Pain, Anxiety, and Sleep in Kidney Transplantation), which is not on this map. Cited by 141 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Sensory Modulation Room Applied in the Preoperative Period on Pain, Anxiety, and Sleep in Kidney Transplantation: An Innovative Nursing Intervention
Who cites it
141 citing papers in PubMed, 4 syntheses or guidelines pooled it, 290 citations in OpenAlex.
- Association Between Physical Activity, Heart Rate Variability and Major Depressive Disorders: An Umbrella Review.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Autonomic responses to aerobic and resistance exercise in patients with chronic musculoskeletal pain: A systematic review.PloS one · 2023Pooled it
- Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review.NeuroRehabilitation · 2018Pooled it
- Transcutaneous Auricular Vagus Nerve Stimulation Attenuates Early Increases in Heart Rate Associated With the Cold Pressor Test.Neuromodulation : journal of the International Neuromodulation Society · 2024Trial
- Tai chi improves psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemic.Experimental gerontology · 2021Trial
- Acute psychological stress, autonomic function, and arterial stiffness among women.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Trial
- The interaction between the immune system and the autonomic nervous system in the pathophysiology of major depressive disorder: a scoping review.Brain, behavior, & immunity - health · 2026Review
- The association between work-family conflict and psychomotor vigilance among women working in aged care services in Japan.Industrial health · 2026Article
- Gut microbiota-driven metabolites modulate the development of stress-related mental disorders.Translational psychiatry · 2026Review
- Prenatal stress alters offspring neurovascular, autonomic, and immune development in animal models of neuropsychiatric and cardiometabolic disorders.Journal of neuroendocrinology · 2026Review
- Deep Learning-Based Heartbeat Detection from 3D Seismocardiography for Robust Heart Rate Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Observational
- A feasibility study exploring precarious employment and stress-related health among women.BMC public health · 2026Article
- Electrocardiogram-Based Mental Stress Detection Amid Everyday Activities Using Machine Learning: Model Development and Validation Study.Journal of medical Internet research · 2026Article
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Physical Activity, Metabolic Risk and the Primary Allostatic Load Mediators: An Explorative Study.Sports (Basel, Switzerland) · 2026Article
- Differential Expression of Hypothalamic Genes in Laying Hens Housed in Caged and Cage-Free Systems Under Commercial Conditions in the Tropics.Animals : an open access journal from MDPI · 2026Article
- Sleep state is superior to resting state for heart rate variability assessment in major depressive disorder.Acta neuropsychiatrica · 2026Article
- Measurement of Serum Parameters Attributes the Therapeutic Effects of Music Therapy to Augmented Stress-Coping Ability and Diminished Systemic Inflammation.Depression and anxiety · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autonomic nervous system is one of the major neural pathways activated by stress. In situations that are often associated with chronic stress, such as major depressive disorder, the sympathetic nervous system can be continuously activated without the normal counteraction of the parasympathetic nervous system. As a result, the immune system can be activated with increased levels of proinflammatory cytokines. These inflammatory conditions have been repeatedly observed in depression. In the search for the mechanism by which the immune system might contribute to depression, the enhanced activity of indoleamine 2,3- dioxygenase by pro-inflammatory cytokines has been suggested to play an important role. Indoleamine 2,3-dioxygenase is the first enzyme in the kynurenine pathway that converts tryptophan to kynurenine. Elevated activity of this enzyme can cause imbalances in downstream kynurenine metabolites. This imbalance can induce neurotoxic changes in the brain and create a vulnerable glial-neuronal network, which may render the brain susceptible to depression. This review focuses on the interaction between stress, the autonomic nervous system and the immune system which can cause imbalances in the kynurenine pathway, which may ultimately lead to major depressive disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.