Evidence map›Paper›PMID 27640304›Full record

ArticleAmerican journal of human genetics2016

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

Maya Ghoussaini, Juliet D French, Kyriaki Michailidou, Silje Nord, Jonathan Beesley, Sander Canisus, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh and 115 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  8. Mitochondrial Ribosomal Proteins and Cancer.Medicina (Kaunas, Lithuania) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

125 authors at 20 institutions in 25 countries.

Maya GhoussainiCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Juliet D FrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia 1683, Cyprus.
Silje NordDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway.
Jonathan BeesleyCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Sander CanisusNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands.
Kristine M HillmanCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Susanne KaufmannCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Haran SivakumaranCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Mahdi Moradi MarjanehCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Jason S LeeCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Ed DicksCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC 3010, Australia.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands.
Annegien BroeksNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands.
Kenneth MuirInstitute of Population Health, University of Manchester, Manchester M13 9PL, UK; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Artitaya LophatananonInstitute of Population Health, University of Manchester, Manchester M13 9PL, UK; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Peter A FaschingDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Matthias W BeckmannDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Olivia FletcherToby Robins Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK; Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.
Nichola JohnsonToby Robins Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK; Division of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Frederik MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
Pascal GuénelCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94807 Villejuif, France.
Thérèse TruongCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94807 Villejuif, France.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Henrik FlygerDepartment of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Javier BenitezHuman Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain; Centro de Investigación en Red de Enfermedades Raras, 46010 Valencia, Spain.
Anna González-NeiraHuman Cancer Genetics Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain.
M Rosario AlonsoHuman Genotyping-CEGEN Unit, Human Cancer Genetic Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain.
Guillermo PitaHuman Genotyping-CEGEN Unit, Human Cancer Genetic Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA 92697, USA.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, CA 92697, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, 81675 Munich, Germany.
Rita K SchmutzlerCenter for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, 50931 Cologne, Germany; Center for Integrated Oncology (CIO), University Hospital of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Hiltrud BrauchGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany; University of Tübingen, 72074 Tübingen, Germany.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Daniel C TessierMcGill University and Génome Québec Innovation Centre, Montréal, QC H3A OG1, Canada.
Daniel VincentMcGill University and Génome Québec Innovation Centre, Montréal, QC H3A OG1, Canada.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, Finland.
Sofia KhanDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, Finland.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Thilo DörkGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.
Natalia V BogdanovaGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany; Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden.
Sara MargolinDepartment of Oncology-Pathology, Karolinska Institutet, 17177 Stockholm, Sweden.
Arto MannermaaCancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70210 Kuopio, Finland.
Veli-Matti KosmaCancer Center of Eastern Finland, University of Eastern Finland, 70211 Kuopio, Finland; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70211 Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, 70210 Kuopio, Finland.
kConFab/AOCS Investigators
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Diether LambrechtsVesalius Research Center, VIB, 3000 Leuven, Belgium; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium.
Giuseppe FlorisUniversity Hospital Gashuisberg, 3000 Leuven, Belgium.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
Monica BarileDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Emily HallbergDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Mark S GoldbergDepartment of Medicine, McGill University, Montreal, QC H3G 2M1, Canada; Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, QC H3A 1A8, Canada.
Soo H TeoCancer Research Initiatives Foundation, Subang Jaya, 47500 Selangor, Malaysia; Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
Cheng Har YipBreast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
Anne-Lise Borresen-DaleDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway.
NBCS Collaborators
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, 90220 Oulu, Finland.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, 90220 Oulu, Finland.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Peter DevileeDepartment of Pathology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Rob A E M TollenaarDepartment of Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh EH8 9AG, UK.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Judith S BrandDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, 3008 AE Rotterdam, the Netherlands.
Linetta B KoppertDepartment of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, 3008 AE Rotterdam, the Netherlands.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, 200336 Shanghai, China.
Angela CoxSheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Valerie RheniusCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Cancer Research Institute, Seoul National University, Seoul 110-799, Korea.
Daehee KangDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Cancer Research Institute, Seoul National University, Seoul 110-799, Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Department of Surgery, National University Health System, Singapore 117597, Singapore.
Kee Seng ChiaSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore.
Maria KabischMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, DC 11001000, Colombia.
Craig LuccariniCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Don M ConroyCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
Suleeporn SangrajrangNational Cancer Institute, Bangkok 10400, Thailand.
Paul BrennanInternational Agency for Research on Cancer, Lyon Cedex 08, France.
Curtis OlswoldUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Susan SlagerUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Chen-Yang ShenSchool of Public Health, China Medical University, Taichung 40402, Taiwan; Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Ming-Feng HouDepartment of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan.
Anthony SwerdlowDivision of Breast Cancer Research, The Institute of Cancer Research, London SW7 3RP, UK; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, QC G1V 4G2, Canada.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Vessela KristensenDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway; Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, 0450 Oslo, Norway.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. Electronic address: amd24@medschl.cam.ac.uk.
Stacey L EdwardsCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Electronic address: stacey.edwards@qimrberghofer.edu.au.
University of Cambridge · GBQIMR Berghofer Medical Research Institute · AUGerman Cancer Research Center · DEKarolinska Institutet · SEInstitute of Cancer Research · GBSpanish National Cancer Research Centre · ESThe University of Melbourne · AUOslo University Hospital · NOThe Netherlands Cancer Institute · NLUniversity of Hawaiʻi at Mānoa · USUniversity of Southern California · USVanderbilt University · USAichi Cancer Center · JPErasmus MC Cancer Institute · NLInserm · FRLeiden University Medical Center · NLMcGill University and Génome Québec Innovation Centre · CAMedizinische Hochschule Hannover · DENational University of Singapore · SGNordLab · FI

Funding

Risk and penetrance of mutations from breast cancer testing panels.R01CA192393 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH, NATHANSON, KATHERINE L. · 2014 to 2018
$6.3M
Identifying and validating novel susceptibility genes for breast cancerR01CA176785 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH, NATHANSON, KATHERINE L. · 2014 to 2018
$3.4M
Consortium Study to Identify Breast Cancer Susceptibility LociR01CA148667 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LONG, JIRONG, ZHENG, WEI · 2011 to 2015
$3.3M
BRCA1 and BRCA2 missense mutations and breast cancer riskU01CA116167 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2013 to 2017
$2.7M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 16565Medical Research Council MC_PC_14105NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS U01 CA116167World Health Organization 001
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495-45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen-receptor-positive (ER

Indexed as

AllelesBreast NeoplasmsCase-Control StudiesCell Line, TumorChromosomes, Human, Pair 5Enhancer Elements, GeneticFibroblast Growth Factor 10Genetic Predisposition to DiseaseHaplotypesHumansPolymorphism, Single NucleotidePromoter Regions, GeneticQuantitative Trait LociReceptor, Fibroblast Growth Factor, Type 2Receptors, EstrogenFGF10 protein, humanFGFR2 protein, humanFibroblast Growth Factor 10Receptor, Fibroblast Growth Factor, Type 2Receptors, Estrogen

Identifiers

PMID27640304
PMCPMC5065698
OpenAlexW2519527699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.