ArticleVirology journal2016
Existence of various human parvovirus B19 genotypes in Chinese plasma pools: genotype 1, genotype 3, putative intergenotypic recombinant variants and new genotypes.
Article in Virology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Overall prevalence of human parvovirus B19 among blood donors in mainland China: A PRISMA-compliant meta-analysis.Medicine · 2020Pooled it
- Human parvovirus B19 infection in dengue patients and potential association with disease progression and clinical outcomes.IJID regions · 2025Article
- Is parvovirus B19 infection upsurge in 2023-2024 associated with adverse pregnancy outcome?Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Review
- Changing epidemiology of parvovirus B19 in the Netherlands since 1990, including its re-emergence after the COVID-19 pandemic.Scientific reports · 2024Article
- The epidemiological and genetic characteristics of human parvovirus B19 in patients with febrile rash illnesses in China.Scientific reports · 2023Article
- Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives.PeerJ · 2023Article
- Identification of human parvovirus 4 genotypes 1 and 2 in Chinese source plasma pools.Journal of medical virology · 2021Article
- Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar.Viruses · 2021Article
- Article
- Molecular screening of the human parvoviruses B19 and bocavirus 1 in the study of congenital diseases as applied to symptomatic pregnant women and children.Access microbiology · 2019Article
- Surveillance of blood donors detects an exceptional Parvovirus B19 outbreak in Switzerland in 2023/2024.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundHuman parvovirus B19 (B19V) is a frequent contaminant of blood and plasma-derived medicinal products. Three distinct genotypes of B19V have been identified. The distribution of the three B19V genotypes has been investigated in various regions or countries. However, in China, data on the existence of different B19V genotypes are limited.
methodsOne hundred and eighteen B19V-DNA positive source plasma pool samples collected from three Chinese blood products manufacturers were analyzed. The subgenomic NS1/VP1u region junction of B19V was amplified by nested PCR. These amplified products were then cloned and subsequently sequenced. For genotyping, their phylogenetic inferences were constructed based on the NS1/VP1-unique region. Then putative recombination events were analyzed and identified.
resultsPhylogenetic analysis of 118 B19V sequences attributed 61.86 % to genotype 1a, 10.17 % to genotype 1b, and 17.80 % to genotype 3b. All the genotype 3b sequences obtained in this study grouped as a specific, closely related cluster with B19V strain D91.1. Four 1a/3b recombinants and 5 new atypical B19V variants with no recombination events were identified.
conclusionsThere were at least 3 subtypes (1a, 1b and 3b) of B19V circulating in China. Furthermore, putative B19V 1a/3b recombinants and unclassified strains were identified as well. Such recombinant and unclassified strains may contribute to the genetic diversity of B19V and consequently complicate the B19V infection diagnosis and NAT screening. Further studies will be required to elucidate the biological significance of the recombinant and unclassified strains.
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