ArticleInternational journal for parasitology. Drugs and drug resistance2016
Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.
Article in International journal for parasitology. Drugs and drug resistance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Unveiling Drimenol: A Phytochemical with Multifaceted Bioactivities.Plants (Basel, Switzerland) · 2024Review
- Review
- Ethnomedicinal study of medicinal plants used by Mizo tribes in Champhai district of Mizoram, India.Journal of ethnobiology and ethnomedicine · 2022Article
- Anthelmintic Agents from African Medicinal Plants: Review and Prospects.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- The Ethyl Acetate Extract of the Marine Edible Gastropod Haliotis tuberculata coccinea: a Potential Source of Bioactive Compounds.Marine biotechnology (New York, N.Y.) · 2021Article
- Natural Products Are a Promising Source for Anthelmintic Drug Discovery.Biomolecules · 2021Review
- Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model.Metabolites · 2021Article
- Nematicidal Activity ofBiomolecules · 2020Article
- Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour.Parasites & vectors · 2019Article
- Review of recent developments in GC-MS approaches to metabolomics-based research.Metabolomics : Official journal of the Metabolomic Society · 2018Review
- Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.Parasites & vectors · 2017Article
- A Community Multi-Omics Approach towards the Assessment of Surface Water Quality in an Urban River System.International journal of environmental research and public health · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
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Abstract
Anthelmintic resistance is widespread in gastrointestinal nematode populations, such that there is a consistent need to search for new anthelmintics. However, the cost of screening for new compounds is high and has a very low success rate. Using the knowledge of traditional healers from Borneo Rainforests (Sarawak, Malaysia), we have previously shown that some traditional medicinal plants are a rich source of potential new anthelmintic drug candidates. In this study, Picria fel-terrae Lour. plant extract, which has previously shown promising anthelmintic activities, was fractionated via the use of a solid phase extraction cartridge and each isolated fraction was then tested on free-living nematode Caenorhabditis elegans and the parasitic nematode Haemonchus contortus. We found that a single fraction was enriched for nematocidal activity, killing ≥90% of C. elegans adults and inhibiting the motility of exsheathed L3 of H. contortus, while having minimal cytotoxic activity in mammalian cell culture. Metabolic profiling and chemometric analysis of the effective fraction indicated medium chained fatty acids and phenolic acids were highly represented.
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