Evidence map›Paper›PMID 27639599›Full record

ReviewPharmacological research2016

DLL4

Lijun Meng, Shaoyan Hu, Jian Wang, Shan He, Yi Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacological research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  12. PeerJ · 2021
    Article
  13. Pleiotropic Role of Notch Signaling in Human Skin Diseases.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lijun MengFels Institute for Cancer Research and Molecular Biology, Temple University, USA.
Shaoyan HuDepartment of Hematology, Children's Hospital, Soochow University, Suzhou, China.
Jian WangDepartment of Hematology, Children's Hospital, Soochow University, Suzhou, China.
Shan HeFels Institute for Cancer Research and Molecular Biology, Temple University, USA.
Yi ZhangFels Institute for Cancer Research and Molecular Biology, Temple University, USA; Department of Microbiology and Immunology, Temple University, USA. Electronic address: yi.zhang@temple.edu.
Soochow University · CNTemple University · USTemple College · US

Funding

Ezh2-mediated Epigenetic Effects and AlloimmunityR01HL127351 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ZHANG, YI · 2016 to 2019
$2.4M
The role of cell death in Lupus NephritisR01AR061569 · NIAMS · TEMPLE UNIV OF THE COMMONWEALTH · PI CARICCHIO, ROBERTO · 2012 to 2016
$2.3M
Delta-like ligand 4+ dendritic cells and induction of alloimmunityR01CA172106 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, YI · 2013 to 2017
$1.6M
Lymphocyte trafficking blockade in allogeneic stem-cell transplantationK23CA178202 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RESHEF, RAN · 2013 to 2015
$520k
NCI NIH HHS K23 CA178202NCI NIH HHS R01 CA172106NHLBI NIH HHS R01 HL127351NIAMS NIH HHS R01 AR061569
6 · The paper itself

Abstract

Dendritic cells (DCs) are critical regulators of adaptive immune responses. DCs can elicit primary T cell responses at low DC:T cell ratios through their expression of high levels of antigen-presenting molecules and costimulatory molecules. DCs are important for induction of functionally diverse T cell subsets such as CD4

Indexed as

AnimalsCell DifferentiationDendritic CellsHumansInflammationIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, NotchSignal TransductionT-Lymphocyte Subsetsdelta proteinIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, NotchAlloimmunity and autoimmunityDLL4DLL4(+) DCsNotch signalingTumor immunity

Identifiers

PMID27639599
PMCPMC5571445
OpenAlexW2520061072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.