Evidence map›Paper›PMID 27639591›Full record

ArticleJournal of nephrology2017

Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers.

Domenico Rendina, Gianpaolo De Filippo, Fernando Gianfrancesco, Riccardo Muscariello, Michele Schiano di Cola, Pasquale Strazzullo, Teresa Esposito

Abstract read
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In one paragraph

Article in Journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  8. Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Domenico RendinaDepartment of Clinical Medicine and Surgery, Federico II University of Naples, via Pansini 5, 80131, Naples, Italy. domenico.rendina@unina.it.ORCID http://orcid.org/0000-0002-0331-0392
Gianpaolo De FilippoInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso", Italian National Research Council, Naples, Italy.
Fernando GianfrancescoAP-HP, CHU Bicêtre, Service de Médecine des Adolescents, Le Kremlin-Bicêtre, France.
Riccardo MuscarielloDepartment of Clinical Medicine and Surgery, Federico II University of Naples, via Pansini 5, 80131, Naples, Italy.
Michele Schiano di ColaDepartment of Clinical Medicine and Surgery, Federico II University of Naples, via Pansini 5, 80131, Naples, Italy.
Pasquale StrazzulloDepartment of Clinical Medicine and Surgery, Federico II University of Naples, via Pansini 5, 80131, Naples, Italy.
Teresa EspositoAP-HP, CHU Bicêtre, Service de Médecine des Adolescents, Le Kremlin-Bicêtre, France.
University of Naples Federico II · ITAssistance Publique – Hôpitaux de Paris · FRFederico II University Hospital · ITInstitute of Genetics and Biophysics · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic factors play a key role in the pathogenesis of hypocitraturia, a common risk factor for nephrolithiasis. The Na

methodsRecurrent calcium-oxalate stone formers (SF) with or without hypocitraturia and healthy controls (C) were genotyped. Gene-gene interactions were estimated by the 1.0 software package of multifactor dimensionality reduction (MDR).

resultsThe prevalence of VDR

conclusionsThese results point to an epistatic interaction between the VDR and the SLC13A2 alleles in the pathogenesis of idiopathic hypocitraturia in calcium-oxalate SF.

Indexed as

Epistasis, GeneticPolymorphism, Single NucleotideAdultBiomarkersCalcium OxalateCase-Control StudiesChi-Square DistributionCitric AcidCross-Sectional StudiesDicarboxylic Acid TransportersFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansBiomarkersCalcium OxalateCitric AcidDicarboxylic Acid TransportersOrganic Anion Transporters, Sodium-DependentReceptors, CalcitriolSLC13A2 protein, humanSymportersVDR protein, humanEpistasisHypocitraturiaNephrolithiasisSLC13A2VDR

Identifiers

PMID27639591
OpenAlexW2519203249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.