Evidence map›Paper›PMID 27639560›Full record

ArticleBMC medical research methodology2016

Onset of persistent pseudomonas aeruginosa infection in children with cystic fibrosis with interval censored data.

Wenjie Wang, Ming-Hui Chen, Sy Han Chiou, Hui-Chuan Lai, Xiaojing Wang, Jun Yan, Zhumin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical research methodology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Wenjie WangDepartment of Statistics, University of Connecticut, 215 Glenbrook Road, Storrs, 06269, CT, USA.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, 215 Glenbrook Road, Storrs, 06269, CT, USA.
Sy Han ChiouDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115, MA, USA.
Hui-Chuan LaiDepartment of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, 53706, WI, USA.
Xiaojing WangGoogle, 76 Ninth Avenue, New York, 10011, NY, USA.
Jun YanDepartment of Statistics, University of Connecticut, 215 Glenbrook Road, Storrs, 06269, CT, USA. jun.yan@uconn.edu.
Zhumin ZhangDepartment of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, 53706, WI, USA.
University of Connecticut · USUniversity of Wisconsin–Madison · USGoogle (United States) · USHarvard University · USUConn Health · US

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
Newborn Screening, Malnutrition and Lung Disease in Children with Cystic FibrosisR01DK072126 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2006 to 2015
$4.3M
Bayesian Approaches to Model Selection for Survival DataR01GM070335 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2003 to 2019
$4.0M
Early Childhood Diet, Growth, Gut Microbiome And Lung Health in Cystic FibrosisR01DK109692 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2016 to 2021
$3.8M
Training in Neurostatistics and NeuroepidemiologyT32NS048005 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ONNELA, JUKKA-PEKKA · 2004 to 2018
$3.2M
NCI NIH HHS P01 CA142538NIDDK NIH HHS R01 DK072126NIDDK NIH HHS R01 DK109692NIGMS NIH HHS R01 GM070335NINDS NIH HHS T32 NS048005
6 · The paper itself

Abstract

backgroundPersistent Pseudomonas aeruginosa (PPA) infection promotes lung function deterioration in children with cystic fibrosis (CF). Although early CF diagnosis through newborn screening (NBS) has been shown to provide nutritional/growth benefit, it is unclear whether NBS lowers the risk of PPA infection and how the effect of NBS vary with age. Modeling the onset age of PPA infection is challenging because 1) the onset age of PPA infection is interval censored in patient registry data; and 2) some risk factors such as NBS may have time-varying effects.

methodsThis problem fits into the framework of a recently developed Bayesian dynamic Cox model for interval censored data, where each regression coefficient is allowed to be time-varying to an extent determined by the data.

resultsApplication of the methodology to data from the CF Foundation Patient Registry revealed interesting findings. Compared with patients with meconium ileus or diagnosed through signs or symptoms, patients diagnosed through NBS had significantly lower risks of acquiring PPA infection between age 1 and 2 years, and the benefit in survival rate was found to last up to age 4 years. Two cohorts of five years apart were compared. Patients born in cohort 2003-2004 had significantly lower risks of the PPA infections at any age up to 4 years than those born in 1998-1999.

conclusionsThe study supports benefits of NBS on PPA infection in early childhood. In addition, our analyses demonstrate that patients in the more recent cohort had significantly lower risks of acquiring PPA infection up to age 4 years, which suggests improved CF treatment and care over time.

Indexed as

Pseudomonas aeruginosaAlgorithmsChild, PreschoolCystic FibrosisEarly DiagnosisFemaleHumansInfantInfant, NewbornMaleMarkov ChainsMonte Carlo MethodNeonatal ScreeningProportional Hazards ModelsPseudomonas InfectionsRiskCox modelDynamic modelReversible jump Markov chain Monte CarloTime-varying effect

Identifiers

PMID27639560
PMCPMC5027124
OpenAlexW2519813767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.