ArticleJournal of the mechanical behavior of biomedical materials2017
Contraction and stress-dependent growth shape the forebrain of the early chicken embryo.
Article in Journal of the mechanical behavior of biomedical materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Brain organoids and genome editing: A new era in understanding human brain development and disorders.Neural regeneration research · 2026Article
- Morphometric analysis reveals that the chick cranial neural tube expands as an active shell.bioRxiv : the preprint server for biology · 2026Article
- Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord.Developmental cell · 2025Article
- Anatomical and Embryological Development of the Chick Cerebrum in Different Embryonic Periods.Veterinary medicine and science · 2025Article
- Article
- Simulating irregular symmetry breaking in gut cross sections using a novel energy-optimization approach in growth-elasticity.Journal of theoretical biology · 2024Article
- Biomechanical models and mechanisms of cellular morphogenesis and cerebral cortical expansion and folding.Seminars in cell & developmental biology · 2023Review
- Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Molecular and mechanical signals determine morphogenesis of the cerebral hemispheres in the chicken embryo.Development (Cambridge, England) · 2019Article
- Mechanics of cortical folding: stress, growth and stability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- How mechanical forces shape the developing eye.Progress in biophysics and molecular biology · 2018Review
- Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis.Journal of visualized experiments : JoVE · 2018Article
- Mechanical Tension Drives Elongational Growth of the Embryonic Gut.Scientific reports · 2018Article
- Apoptosis generates mechanical forces that close the lens vesicle in the chick embryo.Physical biology · 2018Article
- How the embryonic chick brain twists.Journal of the Royal Society, Interface · 2016Article
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4 authors.
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Abstract
During early vertebrate development, local constrictions, or sulci, form to divide the forebrain into the diencephalon, telencephalon, and optic vesicles. These partitions are maintained and exaggerated as the brain tube inflates, grows, and bends. Combining quantitative experiments on chick embryos with computational modeling, we investigated the biophysical mechanisms that drive these changes in brain shape. Chemical perturbations of contractility indicated that actomyosin contraction plays a major role in the creation of initial constrictions (Hamburger-Hamilton stages HH11-12), and fluorescent staining revealed that F-actin is circumferentially aligned at all constrictions. A finite element model based on these findings shows that the observed shape changes are consistent with circumferential contraction in these regions. To explain why sulci continue to deepen as the forebrain expands (HH12-20), we speculate that growth depends on wall stress. This idea was examined by including stress-dependent growth in a model with cerebrospinal fluid pressure and bending (cephalic flexure). The results given by the model agree with observed morphological changes that occur in the brain tube under normal and reduced eCSF pressure, quantitative measurements of relative sulcal depth versus time, and previously published patterns of cell proliferation. Taken together, our results support a biphasic mechanism for forebrain morphogenesis consisting of differential contractility (early) and stress-dependent growth (late).
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