Evidence map›Paper›PMID 27639448›Full record

ReviewNeuroscience and biobehavioral reviews2017

Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.

Mason M Silveira, Jonathon C Arnold, Steven R Laviolette, Cecilia J Hillard, Marta Celorrio, María S Aymerich, Wendy K Adams

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. A randomised controlled trial of vaporised ΔEuropean archives of psychiatry and clinical neuroscience · 2019
    Trial
  2. Adolescent ΔPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Interactions between cannabidiol and ΔBritish journal of pharmacology · 2020
    Article
  12. Terpenoids Commonly Found inCannabis and cannabinoid research · 2020
    Article
  13. Article
  14. Review
  15. Adolescent ΔBiological psychiatry · 2019
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Mason M SilveiraDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: silveira.mason@psych.ubc.ca.
Jonathon C ArnoldThe Brain and Mind Centre and Discipline of Pharmacology, University of Sydney, Sydney, NSW, Australia.
Steven R LavioletteAddiction Research Group and Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Cecilia J HillardDepartment of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Marta CelorrioProgram of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain; Department of Biochemistry and Genetics, School of Science, University of Navarra, Pamplona 31008, Spain.
María S AymerichProgram of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain; Department of Biochemistry and Genetics, School of Science, University of Navarra, Pamplona 31008, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona 31008, Spain.
Wendy K AdamsDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: wendy.adams@ubc.ca.
University of British Columbia · CAMedical College of Wisconsin · USNavarre Institute of Health Research · ESThe University of Sydney · AUUniversidad de Navarra · ESWestern University · CA

Funding

Cannabinoid regulation of glycogen synthase kinase-3R01DA026996 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J · 2010 to 2014
$1.7M
NIDA NIH HHS R01 DA026996
6 · The paper itself

Abstract

Public opinion surrounding the recreational use and therapeutic potential of cannabis is shifting. This review describes new work examining the behavioural and neural effects of cannabis and the endocannabinoid system, highlighting key regions within corticolimbic brain circuits. First, we consider the role of human genetic factors and cannabis strain chemotypic differences in contributing to interindividual variation in the response to cannabinoids, such as THC, and review studies demonstrating that THC-induced impairments in decision-making processes are mediated by actions at prefrontal CB

Indexed as

SmokingAnimalsCannabisEndocannabinoidsHumansReceptor, Cannabinoid, CB1EndocannabinoidsReceptor, Cannabinoid, CB1AEAAmygdalaAnxietyCannabidiolCannabisCB(1) receptorCorticolimbic circuitsDecision-makingElevated plus mazeEmotional salience processingEndocannabinoid systemFAAHHippocampusIndividual differencesMesolimbic dopamine systemPhytocannabinoidsPrefrontal cortexPsychiatric disordersSocial interactionTHC

Identifiers

PMID27639448
PMCPMC5350061
OpenAlexW2518949021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.