ArticleNeurobiology of aging2016
Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Biomarker advancements in cerebral small vessel disease: An overview.Neural regeneration research · 2026Article
- Probabilistic maps of white matter hyperintensity in a Chinese aging cohort and application for clinical diagnosis.European radiology · 2026Article
- Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study.Brain communications · 2025Article
- The AHA/ASA and DSM-V diagnostic criteria for vascular cognitive impairment identify cases with predominant vascular pathology.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Correspondence between white matter hyperintensities and regional grey matter volumes in Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.Frontiers in neurology · 2024Article
- White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer's disease (AD) neuropathology: A hypothesis and review.Frontiers in aging neuroscience · 2023Article
- Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Regional White Matter Hyperintensities and Alzheimer's Disease Biomarkers Among Older Adults with Normal Cognition and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2023Article
- APOE-ε4 modulates the association among plasma AβTranslational psychiatry · 2022Article
- Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology.Acta neuropathologica · 2021Article
- Editorial: Vascular Factors and Vascular Lesions in Pre-clinical Alzheimer's Disease.Frontiers in neurology · 2021Article
- Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults.Stroke · 2021Article
- White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease.Neurology · 2020Article
- White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm.NeuroImage · 2020Article
- Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults.Journal of Alzheimer's disease : JAD · 2020Article
- White matter hypointensities and hyperintensities have equivalent correlations with age and CSF β-amyloid in the nondemented elderly.Brain and behavior · 2019Article
- Cerebral small vessel disease: neuroimaging markers and clinical implication.Journal of neurology · 2019Review
- Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults.Neurobiology of aging · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Cross-sectional studies show that elevated cerebral amyloid is associated with greater white-matter hyperintensity (WMH) burden in cognitively normal (CN) older adults. However, the relative time courses of amyloid and WMH accrual are unclear. To address this, we tested the associations between known WMH correlates-age, hypertension, and amyloid-with WMH accrual rate. We used brain magnetic resonance imaging to measure WMH change in 112 CN Alzheimer's Disease Neuroimaging Initiative (GO/2) participants over a 2-year period. A linear mixed effects model assessed baseline cerebrospinal fluid amyloid beta (Aβ) 1-42, hypertension, age, and their interactions, as predictors of greater WMH accrual. Greater amyloid burden was associated with greater WMH accrual over time. Those with hypertension showed a stronger association between greater amyloid burden and WMH accrual rate. Greater age was not significantly associated with greater WMH accrual in this model. Although the direction of the relationship cannot be tested in this model, CN individuals harboring cerebral amyloid had greater accrual of WMH over a 2-year period after accounting for hypertension and age. Impaired amyloid clearance and cerebral small vessel disease may both underlie the more rapid emergence of WM lesions. The role of cerebral amyloid burden in white-matter injury should thus be considered as a relevant factor when WMHs are detected clinically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.