Evidence map›Paper›PMID 27639119›Full record

ArticleNeurobiology of aging2016

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.

Knut H Lauritzen, Md Mahdi Hasan-Olive, Christine E Regnell, Liv Kleppa, Morten Scheibye-Knudsen, Albert Gjedde, Arne Klungland, Vilhelm A Bohr, Jon Storm-Mathisen, Linda H Bergersen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  13. βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
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  15. Ketogenic Diet in Alzheimer's Disease.International journal of molecular sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Knut H LauritzenSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway.
Md Mahdi Hasan-OliveSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway.
Christine E RegnellSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway; Center for Healthy Aging and Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Liv KleppaSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway.
Morten Scheibye-KnudsenLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Albert GjeddeCenter for Healthy Aging and Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Arne KlunglandInstitute of Medical Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Vilhelm A BohrLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Jon Storm-MathisenSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Linda H BergersenSynaptic Neurochemistry Laboratory, Division of Anatomy and CMBN/SERTA Healthy Brain Ageing Centre, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, University of Oslo, Oslo, Norway; Center for Healthy Aging and Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: l.h.bergersen@odont.uio.no.
University of Oslo · NOUniversity of Copenhagen · DKNational Institutes of Health · USOslo University Hospital · NO

Funding

Mitochondrial DNA Repair Processes In Oxidative Stress And AgingZIAAG000733 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2022
$9.2M
Intramural NIH HHS ZIA AG000733
6 · The paper itself

Abstract

Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we examine whether severe neurodegeneration in mutUNG1-expressing mice could be rescued by feeding the mice a ketogenic diet, which is known to have beneficial effects in several neurological disorders. The diet increased the levels of superoxide dismutase 2, and mitochondrial mass, enzymes, and regulators such as SIRT1 and FIS1, and appeared to downregulate N-methyl-D-aspartic acid (NMDA) receptor subunits NR2A/B and upregulate γ-aminobutyric acid A (GABA

Indexed as

DNA DamageDNA, MitochondrialProsencephalonAnimalsDiet, KetogenicMice, Inbred C57BLMice, TransgenicMicroscopy, ElectronMitochondriaMitochondrial DiseasesNeurodegenerative DiseasesNeuronsOrganelle BiogenesisPeryleneDNA, MitochondrialPeryleneBiogenesisKetogenic dietMtDNA damageNeurodegeneration

Identifiers

PMID27639119
PMCPMC5629920
OpenAlexW2515909219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.