Evidence map›Paper›PMID 27638969›Full record

ArticleGeneral hospital psychiatry

Distribution-based estimates of minimal important difference for hospital anxiety and depression scale and impact of event scale-revised in survivors of acute respiratory failure.

Kitty S Chan, Lisa Aronson Friedman, O Joseph Bienvenu, Victor D Dinglas, Brian H Cuthbertson, Richard Porter, Christina Jones, Ramona O Hopkins, Dale M Needham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kitty S ChanDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: kchan10@jhu.edu.
Lisa Aronson FriedmanOutcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
O Joseph BienvenuOutcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins University Bloomberg, School of Public Health, Baltimore, MD.
Victor D DinglasOutcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brian H CuthbertsonDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada.
Richard PorterGlenfield Hospital, Leicester, UK.
Christina JonesUniversity of Liverpool, Liverpool, UK.
Ramona O HopkinsDepartment of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT, USA; Center for Humanizing Critical Care, Intermountain Health Care, Murray, UT, USA; Psychology Department and Neuroscience Center, Brigham Young University, Provo, UT, USA.
Dale M NeedhamOutcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BROWER, ROY G. · 2003 to 2007
$21.3M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Improving Long-Term Outcomes Clinical Research for Acute Respiratory FailureR24HL111895 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEEDHAM, DALE MURRAY · 2013 to 2017
$5.4M
Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsR01HL091760 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HOPKINS, RAMONA O, NEEDHAM, DALE MURRAY · 2008 to 2011
$2.0M
ICU-ACQUIRED NEUROMUSCULAR DYSFUNCTION AND OUTCOMES IN ACUTE LUNG INJURYR01HL096504 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, NEEDHAM, DALE MURRAY · 2010 to 2013
$1.5M
Chief Scientist Office CZH/4/351Department of Health [UK]NCATS NIH HHS UL1 TR000424NHLBI NIH HHS P50 HL073994NHLBI NIH HHS R01 HL091760NHLBI NIH HHS R01 HL096504NHLBI NIH HHS R24 HL111895
6 · The paper itself

Abstract

objectiveThis study will estimate distribution-based minimal important difference (MID) for the Hospital Anxiety and Depression Scale anxiety (HADS-A) and depression (HADS-D) subscales, and the Impact of Event Scale-Revised (IES-R) in survivors of acute respiratory failure (ARF).

methodsSecondary analyses of data from two US and three UK studies of ARF survivors (total N=1223). HADS-D and HADS-A were used to assess depression and anxiety symptoms. IES-R assessed post-traumatic stress disorder symptoms. Standard error of measurement, minimal detectable change90, 0.5 standard deviation (S.D.), and 0.2 S.D. were used to estimate MID for the combined sample, by studies, 6- and 12-month follow-ups, country and mental health condition.

resultsOverall, MID estimates converged to 2.0-2.5 for the HADS-A, 1.9-2.3 for the HADS-D and 0.17-0.18 for the IES-R. MID estimates were comparable across studies, follow-up, country and mental health condition.

conclusionAmong ARF survivors, 2.0-2.5 is a reasonable range for the MID for both HADS subscales, and 0.2 is reasonable for IES-R. Until anchor-based MIDs for these instruments are available, these distribution-based estimates can help researchers plan future studies and interpret the clinical importance of findings in ARF patient populations.

Indexed as

Data Interpretation, StatisticalAdultAnxietyDepressionFemaleFollow-Up StudiesHumansMaleMiddle AgedPsychiatric Status Rating ScalesRespiratory InsufficiencyStress Disorders, Post-TraumaticSurvivorsAcute respiratory failureHospital anxiety and depression scaleImpact of event scale-revisedMinimal important difference

Identifiers

PMID27638969
PMCPMC5027977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.