ArticleGeneral hospital psychiatry
The prognostic impact and optimal timing of the Patient Health Questionnaire depression screen on 4-year mortality among hospitalized patients with systolic heart failure.
Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02044211 (Blended Collaborative Care for Heart Failure and Co-Morbid Depression), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Association Between Triglyceride-Glucose-Body Mass Index and Depression in Elderly Diabetic Individuals: A Population-Based Study.International journal of endocrinology · 2026Article
- Neuropsychiatric disorders in patients with heart failure: not to be ignored.Heart failure reviews · 2023Review
- Symptom Burden among Hospitalised Older Patients with Heart Failure in Hanoi, Vietnam.International journal of environmental research and public health · 2022Article
- Cognitive impairment and depression in heart failure: 'cardiological giants'.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021Article
- The prevalence of depression, stress and anxiety symptoms in patients with chronic heart failure.International journal of mental health systems · 2021Article
- Post-intensive care syndrome as a predictor of mortality in patients with critical illness: A cohort study.PloS one · 2021Article
- Psychosocial Syndemics and Multimorbidity in Patients with Heart FailureJournal of psychiatry and brain science · 2021Article
- Functional support and burden among out-of-home supporters of heart failure patients with and without depression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Article
- Emotion regulation in patients with heart failure: Its relationship with depressive symptoms and rehospitalization.Journal of psychosomatic research · 2019Article
- Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure.Internal medicine (Tokyo, Japan) · 2019Observational
- The effect of diet, lifestyle and psychological factors in the prognosis of ischemic heart failure.Metabolism open · 2019Article
- Affective and cognitive rather than somatic symptoms of depression predict 3-year mortality in patients on chronic hemodialysis.Scientific reports · 2018Article
- Antidepressant use in patients with heart failure.General hospital psychiatryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveAn American Heart Association (AHA) Science Advisory recommends patients with coronary heart disease undergo routine screening for depressive symptoms with the two-stage Patient Health Questionnaire (PHQ). However, little is known on the prognostic impact of a positive PHQ screen on heart failure (HF) mortality.
methodsWe screened hospitalized patients with systolic HF (left ventricle ejection fraction≤40%) for depression with the two-item Patient Health Questionnaire (PHQ-2) and administered the follow-up nine-item Patient Health Questionnaire (PHQ-9) both immediately following the PHQ-2 and by telephone 1 month after discharge. Later, we ascertained vital status at 4-year follow-up on all patients who completed the inpatient PHQ-9 and calculated mortality incidence and risk by baseline PHQ.
resultsOf the 520 HF patients we enrolled, 371 screened positive for depressive symptoms on the PHQ-2. Of these, 63% scored PHQ-9≥10 versus 24% of those who completed the PHQ-9 1 month later (P<.001). PHQ-2 positive status was an independent predictor of 4-year all-cause mortality (HR: 1.50; P=.04), and mortality incidence was similar by baseline PHQ-9 score.
conclusionsAmong hospitalized patients with systolic HF, a positive PHQ-2 screen for depressive symptoms is an independent risk factor for increased 4-year all-cause mortality. Our findings extend the AHA's Science Advisory for depression to hospitalized patients with systolic HF.
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