ArticleThe Journal of infectious diseases2016
Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.
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Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The impact of malaria coinfection on Ebola virus disease outcomes: A systematic review and meta-analysis.PloS one · 2021Pooled it
- A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Pooled it
- Molecular Phenotypes of Sex- and Age-Specific Differences Relating to Outcome in Patients With Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Identification of Host Gene Transcripts by Machine Learning and Their Application to Predict Outcome in Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Strengthening diagnostic capacity for viral hemorrhagic fevers in Forest Guinea: advances in Lassa fever case detection.Npj viruses · 2026Article
- Prognostic Value of PCR Cycle Threshold Value in Crimean-Congo Hemorrhagic Fever, Iraq, 2022-2023.Emerging infectious diseases · 2026Article
- Ebola virus matrix protein VP40 triggers inflammatory responses linked to the ebolavirus virulence.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Discontinuous EBOV RNA synthesis events in patients with Ebola virus disease and their relationship to viral load and outcome of infection.Journal of virology · 2025Article
- Clinical features of Marburg virus disease: a review of all reported patients since 1967.EClinicalMedicine · 2025Review
- Training the Next Generation of Infectious Disease Researchers: A Biorisk Management Module Embedded in a European Master Program.Applied biosafety : journal of the American Biological Safety Association · 2024Article
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- Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care.Genome medicine · 2021Article
- Screening High-Risk Groups and the General Population for SARS-CoV-2 Nucleic Acids in a Mobile Biosafety Laboratory.Frontiers in public health · 2021Article
- Evaluating case definitions for Ebola virus disease.The Lancet. Infectious diseases · 2020Article
- Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease.Genome biology · 2020Article
- Viral genomics in Ebola virus research.Nature reviews. Microbiology · 2020Review
- Sociodemographic and clinical determinants of in-facility case fatality rate for 938 adult Ebola patients treated at Sierra Leone Ebola treatment center.BMC infectious diseases · 2020Article
- Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes.Cell reports · 2020Article
- Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages.Viruses · 2019Article
- Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study.The Journal of infectious diseases · 2019Observational
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Authors and funding
85 authors at 20 institutions in 14 countries.
Romy KerberBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Ralf KrumkampBernhard Nocht Institute for Tropical Medicine German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Boubacar DialloWorld Health Organization.
Anna JaegerBernhard Nocht Institute for Tropical Medicine German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Martin RudolfBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Simone LaniniEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Joseph Akoi BoreEuropean Mobile Laboratory Consortium Ministry of Health Guinea.
Fara Raymond KoundounoEuropean Mobile Laboratory Consortium Ministry of Health Guinea.
Beate Becker-ZiajaBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Erna FleischmannEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Bundeswehr Institute of Microbiology, Munich.
Kilian StoeckerEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Bundeswehr Institute of Microbiology, Munich.
Silvia MeschiEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Stéphane MélyEuropean Mobile Laboratory Consortium National Reference Center for Viral Hemorrhagic Fevers Laboratoire P4 Inserm-Jean Mérieux.
Edmund N C NewmanEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Fabrizio CarlettiEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Jasmine PortmannEuropean Mobile Laboratory Consortium Spiez Laboratory, Federal Office for Civil Protection.
Misa KorvaEuropean Mobile Laboratory Consortium Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia.
Svenja WolffEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Peter MolkenthinEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Bundeswehr Institute of Microbiology, Munich.
Zoltan KisEuropean Mobile Laboratory Consortium National Biosafety Laboratory, National Center for Epidemiology, Budapest, Hungary.
Anne KelterbaumEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Anne BocquinEuropean Mobile Laboratory Consortium National Reference Center for Viral Hemorrhagic Fevers Laboratoire P4 Inserm-Jean Mérieux.
Thomas StreckerEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Alexandra FizetEuropean Mobile Laboratory Consortium National Reference Center for Viral Hemorrhagic Fevers Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Lyon, France.
Concetta CastillettiEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Gordian SchudtEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Lisa OttowellEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Andreas KurthEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Barry AtkinsonEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Marlis BaduscheBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Angela CannasEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Elisa PallaschBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Andrew BosworthEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Constanze YueEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Bernadett PályiEuropean Mobile Laboratory Consortium National Biosafety Laboratory, National Center for Epidemiology, Budapest, Hungary.
Heinz EllerbrokEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Claudia KohlEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Lisa OestereichBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Christopher H LogueEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Anja LüdtkeEuropean Mobile Laboratory Consortium Heinrich Pette Institute-Leibniz Institute for Experimental Virology, Hamburg German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Martin RichterEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Didier NgaboEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Benny BorremansEuropean Mobile Laboratory Consortium Evolutionary Ecology Group, Department of Biology, University of Antwerp.
Dirk BeckerEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Sophie GryseelsEuropean Mobile Laboratory Consortium Evolutionary Ecology Group, Department of Biology, University of Antwerp.
Saïd AbdellatiEuropean Mobile Laboratory Consortium Institute of Tropical Medicine, Antwerp.
Tine VermoesenEuropean Mobile Laboratory Consortium Institute of Tropical Medicine, Antwerp.
Eeva KuismaEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Annette KrausEuropean Mobile Laboratory Consortium Public Health Agency of Sweden, Solna.
Britta LiedigkBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Piet MaesEuropean Mobile Laboratory Consortium Department of Microbiology and Immunology, Rega Institute, KU Leuven.
Ruth ThomEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Sophie DuraffourEuropean Mobile Laboratory Consortium Department of Microbiology and Immunology, Rega Institute, KU Leuven.
Sandra DiederichEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Insel Riems, Germany.
Julia HinzmannEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Babak AfroughEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Johanna RepitsEuropean Mobile Laboratory Consortium Janssen-Cilag, Stockholm, Sweden.
Marc MertensEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Insel Riems, Germany.
Inês VitorianoEuropean Mobile Laboratory Consortium Public Health England, Porton Down.
Amadou BahEuropean Mobile Laboratory Consortium Swiss Tropical and Public Health Institute, Basel.
Andreas SachseEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Jan Peter BoettcherEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Stephanie WurrBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Sabrina BockholtBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Andreas NitscheEuropean Mobile Laboratory Consortium Robert Koch Institute, Berlin.
Tatjana Avšič ŽupancEuropean Mobile Laboratory Consortium Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia.
Marc StrasserEuropean Mobile Laboratory Consortium Spiez Laboratory, Federal Office for Civil Protection.
Giuseppe IppolitoEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Stephan BeckerEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Institute of Virology, Philipps University Marburg.
Herve RaoulEuropean Mobile Laboratory Consortium Laboratoire P4 Inserm-Jean Mérieux.
Miles W CarrollEuropean Mobile Laboratory Consortium Public Health England, Porton Down South General Hospital, University of Southampton, United Kingdom.
Hilde De ClerckMédecins Sans Frontières, Brussels, Belgium.
Michel Van HerpMédecins Sans Frontières, Brussels, Belgium.
Armand SprecherMédecins Sans Frontières, Brussels, Belgium.
Lamine KoivoguiInstitut National de Santé Publique.
N'Faly MagassoubaUniversité Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Guinea.
Sakoba KeïtaMinistry of Health Guinea.
Patrick DruryWorld Health Organization, Geneva, Switzerland.
Cèline GurryWorld Health Organization, Geneva, Switzerland.
Pierre FormentyWorld Health Organization, Geneva, Switzerland.
Jürgen MayBernhard Nocht Institute for Tropical Medicine German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Martin GabrielBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Roman WölfelEuropean Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems Bundeswehr Institute of Microbiology, Munich.
Stephan GüntherBernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
Antonino Di CaroEuropean Mobile Laboratory Consortium National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
German Center for Infection Research · DEPublic Health England · GBRobert Koch Institute · DEBernhard Nocht Institute for Tropical Medicine · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITMédecins Sans Frontières · BEWorld Health Organization · CHInstitute of Virology of the Slovak Academy of Sciences · SKInstitut für Mikrobiologie der BundeswehrInstituut voor Tropische Geneeskunde · BELaboratoire National de Référence · MANational Center for Epidemiology · HURega Institute for Medical Research · BESpiez Laboratory · CHUniversity of Antwerp · BEUniversity of Ljubljana · SIGamal Abdel Nasser University of Conakry · GNInstitut Pasteur · FRLe Laboratoire P4 Inserm Jean Mérieux · FR
Funding
World Health Organization 001
Abstract
backgroundA unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015.
methodsThe unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively.
resultsThe cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome.
conclusionsVirus load, age, and malaria parasite coinfection play a role in the outcome of EVD.
Indexed as
EpidemicsMobile Health UnitsAdolescentAdultAgedChildChild, PreschoolClinical Laboratory ServicesEbolavirusFemaleFiloviridaeFiloviridae InfectionsGuineaHemorrhagic Fever, EbolaHumansInfantRNA, ViralEbola virus diseaseepidemicFilovirusGuineamalariamobile laboratory
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