ArticleNeurology2016
Mechanisms of memory impairment in epilepsy depend on age at disease onset.
Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Diagnostic Challenges in the Neuropsychology of Epilepsy: Report of the ILAE Neuropsychology Task Force Diagnostic Methods Commission: 2021-2025.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Neuropsychological morbidity in the First Seizure Clinic: Prominent mood symptoms and memory issues in epilepsy.Epilepsia open · 2025Article
- Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment.Biomolecules · 2025Article
- Gray matter abnormalities and memory impairment in left mesial temporal lobe epilepsy.Frontiers in human neuroscience · 2025Article
- Article
- The effects of slow wave sleep characteristics on semantic, episodic, and procedural memory in people with epilepsy.Frontiers in pharmacology · 2024Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life.Frontiers in psychology · 2023Article
- Alpha-pinene moderates memory impairment induced by kainic acid via improving the BDNF/TrkB/CREB signaling pathway in rat hippocampus.Frontiers in molecular neuroscience · 2023Article
- Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy.NPJ genomic medicine · 2022Article
- Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures.Frontiers in neurology · 2022Review
- Cognitive dysfunction in Nigerian women with epilepsy on carbamazepine and levetiracetam monotherapy.Brain and behavior · 2021Observational
- Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.Epilepsia · 2020Article
- Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy.Neurobiology of disease · 2019Review
- Article
- Paradigm Shifts in the Neuropsychology of Epilepsy.Journal of the International Neuropsychological Society : JINS · 2017Review
- Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account.Current neurology and neuroscience reports · 2017Review
- Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks.NeuroImage. Clinical · 2017Article
- The Contribution of Cognitive Networks to Depression in Epilepsy.Epilepsy currentsArticle
- The Effects of the Fraction Isolated from IranianIranian journal of pharmaceutical research : IJPRArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, we aimed to uncover distinct antecedents of autobiographic memory dysfunction in patients with epilepsy with early (childhood/adolescence) vs late (adulthood) disease onset.
methodsOne hundred sixty-six adults participated: 92 patients with focal epilepsy, whose cognitive and psychiatric functioning were compared to that of 74 healthy controls. Predictors of autobiographic memory deficit were contrasted between patients with early-onset (n = 47) vs late-onset (n = 45) epilepsy.
resultsOverall, people with epilepsy performed significantly worse on measures of both semantic and episodic autobiographic memory and showed markedly high rates of depressive symptoms and disorders (p < 0.001). Reduced autobiographic memory in patients with early-onset epilepsy was associated with young age at onset, more frequent seizures, and reduced working memory. In contrast, the difficulty that patients with late-onset epilepsy had in recalling autobiographic information was linked to depression and the presence of an MRI-identified lesion.
conclusionsThis study reveals that memory deficits in people with focal epilepsy have differing antecedents depending on the timing of the disease onset. While neurobiological factors strongly underpin reduced autobiographic function in patients with early-onset epilepsy, psychological maladjustment gives rise to the impairments seen in patients with late-onset epilepsy. More broadly, these findings support the practice of subtyping patients according to distinct clinical characteristics to find individualized predictors of cognitive dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.