ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2017
An investigation of APOL1 risk genotypes and preterm birth in African American population cohorts.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of Apolipoprotein L1-Associated Pregnancy Complications on Kidney Disease Phenotypes in a HIV-Associated Nephropathy Mouse Model.Kidney360 · 2026Article
- Review
- Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Pediatric contributions and lessons learned from the NEPTUNE cohort study.Pediatric nephrology (Berlin, Germany) · 2024Review
- The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.Neonatology · 2023Article
- Article
- Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Association of preeclampsia with infant APOL1 genotype in African Americans.BMC medical genetics · 2020Article
- Maternal variants within the apolipoprotein L1 gene are associated with preeclampsia in a South African cohort of African ancestry.European journal of obstetrics, gynecology, and reproductive biology · 2020Article
- Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature.Frontiers in pediatrics · 2020Article
- Fetal-Not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry.American journal of human genetics · 2018Article
- Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry.Current opinion in pediatrics · 2018Review
- NephCure Accelerating Cures Institute: A Multidisciplinary Consortium to Improve Care for Nephrotic Syndrome.Kidney international reports · 2018Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTwo genetic variants in apolipoprotein L1 (APOL1) are associated with increased risk of focal segmental glomerulosclerosis as well as other glomerular phenotypes. These risk variants are common in individuals of African ancestry but absent in other racial groups. Yet, the majority of individuals with two APOL1 risk alleles [high-risk (HR) genotype] do not have renal disease. It is critical to identify environmental and secondary genetic influences that, when combined with these alleles, lead to kidney disease. In a recent study of black children with glomerular disease enrolled in the Nephrotic Syndrome Study Network (NEPTUNE) and Chronic Kidney Disease in Children Study (n = 104), we found that subjects with an HR genotype had a 4.6-fold increase in the odds of preterm birth as compared to those with a low risk (LR) genotype [odds ratio 4.6 (CI 1.4-15.5)]. There are known racial disparities in preterm birth, which itself is a known risk factor for chronic kidney disease and focal segmental glomerulosclerosis. Thus, we questioned whether an HR APOL1 genotype is associated with prematurity in the general African American population.
methodsWe analyzed two publically available genetic datasets of preterm birth in African Americans, including 867 infants and 519 mothers from the Gene Environment Association Studies (GENEVA) study of preterm delivery and 960 mothers from the Boston Medical Center genome-wide association study of preterm birth. We performed multivariable analyses testing for association between HR APOL1 and birth outcomes.
resultsIn both studies, there was no association between HR APOL1 in mothers and prematurity, gestational age or birthweight. Additionally, in the GENEVA study, we saw no association between infant HR APOL1 and prematurity, gestational age or birthweight.
conclusionFrom these data, we conclude that the previously observed association between HR APOL1 and prematurity is specific to those with glomerular disease, suggesting prematurity may act as an additional risk factor in APOL1-associated renal disease.
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