Evidence map›Paper›PMID 27638901›Full record

ArticleThe international journal of neuropsychopharmacology2017

Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making.

Paul Faulkner, Federico Mancinelli, Patricia L Lockwood, Mar Matarin, Raymond J Dolan, Nick W Wood, Peter Dayan, Jonathan P Roiser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Paul FaulknerInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Federico MancinelliInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Patricia L LockwoodInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Mar MatarinInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Raymond J DolanInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Nick W WoodInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Peter DayanInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California.
Jonathan P RoiserGatsby Computational Neuroscience Unit, and CoMPLEX Centre for Mathematics, Physics and Engineering in the Life Sciences and Experimental Biology, University College London, London, United Kingdom; Experimental Psychology, University of Oxford, Oxford, United Kingdom; Clinical and Experimental Epilepsy, Institute of Neurology, and Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom; Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom.
University College London · GBUniversity of California, Los Angeles · USUniversity of Oxford · GB

Funding

Medical Research CouncilWellcome Trust 091593Wellcome Trust 098362
6 · The paper itself

Abstract

Background: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. Methods: Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making. Participants performed a task in which they chose between successive pairs of fixed, lower-stakes (control) and variable, higher-stakes (experimental) gambles, each involving wins or losses. In 21 participants, mRNA from 9 serotonin system genes was measured in whole blood prior to acute tryptophan depletion: 5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT3A, 5-HT3E, 5-HT7 (serotonin receptors), 5-HTT (the serotonin transporter), and tryptophan hydroxylase 1. Results: Acute tryptophan depletion did not significantly influence participants' sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Significant positive correlations, which survived correction for multiple comparisons, were detected between baseline 5-HT1B mRNA levels and acute tryptophan depletion-induced increases in both the overall tendency to choose the experimental gamble and sensitivity to wins. No significant relationship was observed with any other peripheral serotonin system markers. Computational analyses of decision-making data provided results consistent with these findings. Conclusions: These results suggest that the 5-HT1B receptor may modulate the effects of acute tryptophan depletion on risky decision-making. Peripheral levels of serotonin markers may predict response to treatments that act upon the serotonin system, such as selective serotonin reuptake inhibitors.

Indexed as

AdultAnxietyDecision MakingDouble-Blind MethodFemaleGamblingHumansMaleNeuropsychological TestsReaction TimeReceptor, Serotonin, 5-HT1BRNA, MessengerSex CharacteristicsTryptophanReceptor, Serotonin, 5-HT1BRNA, MessengerTryptophan5-HT1Bacute tryptophan depletiondecision-makingriskserotonin

Identifiers

PMID27638901
PMCPMC5480594
OpenAlexW2520651498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.