ArticleAmerican journal of physiology. Heart and circulatory physiology2016
Vascular function assessed by passive leg movement and flow-mediated dilation: initial evidence of construct validity.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of ischemic conditioning on microvascular reactivity to single passive limb movement in young adults: a pilot study.European journal of applied physiology · 2025Trial
- Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.Physiological reports · 2025Trial
- Exercise training improves vascular function in patients with Alzheimer's disease.European journal of applied physiology · 2020Trial
- Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study.Revista Brasileira de terapia intensivaTrial
- The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Endothelial Dysfunction in Systemic Sclerosis: The Passive Leg Movement Technique in the Assessment of Nitric Oxide-Mediated Vascular Impairment.ACR open rheumatology · 2026Article
- Vascular and skeletal muscle oxidative capacity responses to continuous double and single leg cycling.Experimental physiology · 2026Article
- Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025Review
- Vascular dysfunction in COPD with and without chronic respiratory failure: a cross-sectional study.Frontiers in physiology · 2025Article
- Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries.International journal of molecular sciences · 2024Review
- Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?American journal of physiology. Heart and circulatory physiology · 2023Article
- Uphill versus downhill high-intensity training effectiveness in preserving vascular function and exercise performance in runners who reduce their regular endurance training.Sport sciences for health · 2023Article
- Associations between noninvasive upper- and lower-limb vascular function assessments: extending the evidence to young women.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Influence of Local Muscle Cooling on Mitochondrial-Related Gene Expression at Rest.International journal of environmental research and public health · 2022Article
- Reliability of the passive leg movement assessment of vascular function in men.Experimental physiology · 2022Article
- Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Evidence of reduced peripheral microvascular function in young Black women across the menstrual cycle.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2021Article
- Indices of leg resistance artery function are independently related to cycling V̇OPhysiological reports · 2020Article
- Passive leg movement in chronic obstructive pulmonary disease: evidence of locomotor muscle vascular dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The vasodilatory response to passive leg movement (PLM) appears to provide a novel, noninvasive assessment of vascular function. However, PLM has yet to be compared with the established noninvasive assessment of vascular health, flow-mediated dilation (FMD). Therefore, as an initial evaluation of the construct validity of PLM and upright seated and supine PLM as well as brachial (BA) and superficial femoral (SFA) artery FMDs were performed in 10 young (22 ± 1) and 30 old (73 ± 2) subjects. During upright seated PLM, the peak change in leg blood flow (ΔLBF) and leg vascular conductance (ΔLVC) was significantly correlated with BA (r = 0.57 and r = 0.66) and SFA (r = 0.44 and r = 0.41, ΔLBF and ΔLVC, respectively) FMD. Furthermore, although the relationships were not as strong, the supine PLM response was also significantly correlated with BA (r = 0.38 and r = 0.35) and SFA (r = 0.39 and r = 0.35, ΔLBF and ΔLVC, respectively) FMD. Examination of the young and old separately, however, revealed that significant relationships persisted in both groups only for the upright seated PLM response and BA FMD (young: r = 0.73 and r = 0.77; old: r = 0.35 and r = 0.45, ΔLBF and ΔLVC, respectively). Normalizing FMD for shear rate during PLM abrogated all significant relationships between the PLM and FMD response, suggesting a role for nitric oxide (NO) in these associations. Collectively, these data indicate that PLM, particularly upright seated PLM, likely provides an index of vascular health analogous to the traditional FMD test. Given the relative ease of PLM implementation, these data have important positive implications for PLM as a clinical vascular health assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.