Trial reportAmerican journal of physiology. Heart and circulatory physiology2016
Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes.
Trial report in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Comparative effectiveness of various exercise modalities on arterial stiffness and endothelial function in older adults: a systematic review and network meta-analysis of randomised controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Pooled it
- The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2024Pooled it
- Acute Effects of High-Intensity Interval Training on Diabetes Mellitus: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.Current atherosclerosis reports · 2019Pooled it
- Resistance training alone reduces systolic and diastolic blood pressure in prehypertensive and hypertensive individuals: meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Pooled it
- Report results: Impact of whole-body resistance exercise timing on mitigating hyperglycaemia-induced vascular dysfunction in healthy adults.Experimental physiology · 2026Trial
- HIIE Protocols Promote Better Acute Effects on Blood Glucose and Pressure Control in People with Type 2 Diabetes than Continuous Exercise.International journal of environmental research and public health · 2022Trial
- Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study.Revista Brasileira de terapia intensivaTrial
- Impact of a combined lower carbohydrate and Mediterranean diet on metabolic syndrome severity: protocol for a randomised controlled trial.The British journal of nutrition · 2026Article
- Article
- Decreased flow-mediated dilation in healthy Chinese adolescent with a family history of type 2 diabetes.BMC cardiovascular disorders · 2022Article
- Article
- Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease.World journal of cardiology · 2021Review
- Greater increase in internal carotid artery shear rate during aerobic interval compared to continuous exercise in healthy adult men.Physiological reports · 2021Article
- Review
- Moderate-to-Vigorous-Intensity Physical Activity Observed in People With Diabetes-Related Foot Ulcers Over a One-Week Period.Journal of diabetes science and technology · 2019Article
- Do Older People with Diabetes Meet the Recommended Weekly Physical Activity Targets? An Analysis of Objective Physical Activity Data.International journal of environmental research and public health · 2019Article
- Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats.International journal of environmental research and public health · 2019Article
- Effects of resistance exercise on endothelial progenitor cell mobilization in women.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Different modes of exercise, disease, and training status can modify endothelial shear stress and result in distinct effects on endothelial function. To date, no study has examined the influence of type 2 diabetes (T2D) and training status on the acute endothelial response to different modes of interval exercise (INT). We examined the effect of a single session of resistance- and cardio-based INT compared with a time-matched control on endothelial function in 12 age-matched T2D participants, 12 untrained, and 11 trained adults (aged 56 ± 7 yr). Flow-mediated dilation (%FMD) of the brachial artery was assessed at baseline and immediately, 1, and 2 h after an acute bout of cardio interval (C-INT), resistance interval (R-INT), and seated control (CTL); these interventions were randomized and separated by >2 days. C-INT involved seven 1-min cycling intervals at 85% of peak power with 1-min recovery between. R-INT involved the same pattern of seven 1-min intervals using leg resistance exercises. Endothelial function (%FMD) was improved after R-INT in all groups (Condition × Time interaction, P < 0.01), an effect that was most robust in T2D where %FMD was higher immediately (+4.0 ± 2.8%), 1 h (+2.5 ± 2.5%), and 2 h (+1.9 ± 1.9%) after R-INT compared with CTL (P < 0.01 for all). C-INT improved %FMD in T2D at 1-h postexercise (+1.6 ± 2.2%, P = 0.03) compared with CTL. In conclusion, R-INT acutely improves endothelial function throughout the 2-h postexercise period in T2D patients. The long-term impact of resistance exercise performed in an interval pattern is warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.