Evidence map›Paper›PMID 27638850›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2017

Challenging the complementarity of different metrics of left atrial function: insight from a cardiomyopathy-based study.

Yukari Kobayashi, Kegan J Moneghetti, Kalyani Boralkar, Myriam Amsallem, Mirela Tuzovic, David Liang, Phillip C Yang, Sanjiv Narayan, Tatiana Kuznetsova, Joseph C Wu and 2 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  6. Assessment of the ability of the CHABMC cardiovascular disorders · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yukari KobayashiDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Kegan J MoneghettiDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Kalyani BoralkarDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Myriam AmsallemDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Mirela TuzovicDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
David LiangDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Phillip C YangDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Sanjiv NarayanDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Tatiana KuznetsovaResearch Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Joseph C WuDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Ingela SchnittgerDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Francois HaddadDivision of Cardiovascular Medicine, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Cardiovascular Institute of the South · USStanford Medicine · USKU Leuven · BE

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
The Maintenance of Human Atrial FibrillationK24HL103800 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NARAYAN, SANJIV M · 2010 to 2019
$1.9M
NHLBI NIH HHS K24 HL103800NHLBI NIH HHS R01 HL083359
6 · The paper itself

Abstract

aimsLeft ventricular (LV) strain provides incremental values to LV ejection fraction (LVEF) in predicting outcome. We sought to investigate if similar relationship is observed between left atrial (LA) emptying fraction and LA strain. METHODS AND

resultsIn this study, we selected 50 healthy subjects, 50 patients with dilated, 50 hypertrophic, and 50 infiltrative (light-chain (AL) amyloidosis) cardiomyopathy (CMP). Echocardiographic measures included LVEF and LA emptying fraction as well as LV and LA longitudinal strain (LVLS and LALS). After regression analysis, comparison of least square means of LA strain among aetiologies was performed. Intraclass correlation coefficient (ICC) and coefficient of variation (COV) were used in the assessment of variability and reproducibility of LV and LA metrics. The mean LVLS and all LA metrics were impaired in patients with all CMP compared with healthy subjects. In contrast to the moderate relationship between LVEF and LVLS (r = -0.51, P < 0.001), there was a strong linear relationship between LA emptying fraction and LA strain (r = 0.87, P < 0.001). In multiple regression analysis, total LA strain was associated with LVLS (β = -0.48, P < 0.001), lateral E/e' (β = -0.24, P < 0.001), age (β = -0.21, P < 0.001), and heart rate (β = -0.14, P = 0.02). The least square mean of LA strain adjusted for the parameters was not different among aetiologies (ANOVA P = 0.82). The ICC (>0.77) and COV (<13) were acceptable.

conclusionIn contrast to LV measures, there is a strong linear relationship between volumetric and longitudinal deformation indices of left atrium irrespective of CMP aetiology. Either LA emptying fraction or LA strain could be used as an important parameter in predictive models.

Indexed as

AgedAnalysis of VarianceAtrial Function, LeftCardiomyopathy, DilatedCardiomyopathy, HypertrophicCase-Control StudiesEchocardiography, DopplerFemaleHeart AtriaHumansMaleMiddle AgedObserver VariationReference ValuesRegistriesRegression Analysisleft atrial functionleft ventricular functionstrain imaging

Identifiers

PMID27638850
PMCPMC5837570
OpenAlexW2519876685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.