ArticleEnvironmental science and pollution research international2016
Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 70 citations in OpenAlex.
- Assessment of cytotoxicity and genomic instability induced by coal-derived nanoparticles in V79 and HaCaT Cells.Archives of toxicology · 2026Article
- Cross-sectional analysis of dyslipidemia risk in coal mine workers: from epidemiology to animal models.Scientific reports · 2024Article
- The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals.Environmental geochemistry and health · 2023Review
- The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress.Environmental geochemistry and health · 2023Article
- Toxicological Profile of PM from Different Sources in the Bronchial Epithelial Cell Line BEAS-2B.Toxics · 2023Article
- Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis.Respirology (Carlton, Vic.) · 2022Article
- Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies.Particle and fibre toxicology · 2022Article
- No association between pyrite content and lung cell responses to coal particles.Scientific reports · 2021Article
- Comparative Toxicity of Fly Ash: An In Vitro Study.Molecules (Basel, Switzerland) · 2021Article
- RNA-seq-Based Screening in Coal Dust-Treated Cells IdentifiedBioMed research international · 2021Article
- Effects of coal microparticles on marine organisms: A review.Toxicology reports · 2021Article
- Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure.Genetics and molecular biology · 2020Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to coal and coal ashes can cause harmful effects in in vitro and in vivo systems, mainly by the induction of oxidative damage. The aim of this work was to assess cytotoxic and genotoxic effects using the V79 cell line treated with coal and coal fly ash particles derived from a coal power plant located in Santa Catarina, Brazil. Two coal samples (COAL11 and COAL16) and two coal fly ash samples (CFA11 and CFA16) were included in this study. COAL16 was co-firing with a mixture of fuel oil and diesel oil. The comet assay data showed that exposure of V79 cells to coal and coal fly ash particles induced primary DNA lesions. Application of lesion-specific endonucleases (FPG and ENDO III) demonstrated increased DNA effects indicating the presence of high amounts of oxidative DNA lesions. The cytokinesis-block micronucleus cytome assay analysis showed that exposure of V79 cells to high concentrations of coal and coal fly ash particles induced cytotoxic effects (apoptosis and necrosis) and chromosomal instability (nucleoplasmic bridges, nuclear buds, and micronucleus (MN) formation). These results may be associated with compounds contained in the surface of the particles as hazardous elements, ultrafine/nanoparticles, and polycyclic aromatic hydrocarbons (PAHs) which were detected in the samples. Graphical abstract ᅟ.
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