ArticleJournal of the American Heart Association2016
Weight Gain Trajectories Associated With Elevated C-Reactive Protein Levels in Chinese Adults.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The impact of time-restricted eating on health-related quality of life: a systematic literature review.Nutrition reviews · 2025Pooled it
- Early-pregnancy per- and polyfluoroalkyl substances and maternal post-pregnancy weight trajectory.Obesity (Silver Spring, Md.) · 2025Article
- Analysis of different plant- and animal-based dietary patterns and their relationship with serum uric acid levels in Chinese adults.Nutrition journal · 2023Article
- The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status.International journal of molecular sciences · 2023Article
- Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level.Scientific reports · 2022Article
- Concurrent presence of high serum uric acid and inflammation is associated with increased incidence of type 2 diabetes mellitus in Korean adult population.Scientific reports · 2022Article
- Prepregnancy body mass index, gestational weight gain, and maternal prepartum inflammation in normal pregnancies: findings from a Chinese cohort.BMC pregnancy and childbirth · 2022Article
- Article
- Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery.Obesity surgery · 2021Article
- BMI trajectory and subsequent risk of type 2 diabetes among middle-aged women.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Article
- Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults.Scientific reports · 2021Article
- The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study.Pediatric investigation · 2021Article
- Age of obesity onset, cumulative obesity exposure over early adulthood and risk of type 2 diabetes.Diabetologia · 2020Article
- Article
- Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE).Health and quality of life outcomes · 2019Article
- Association Between Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain, and Offspring Atopic Dermatitis: A Prospective Cohort Study.The journal of allergy and clinical immunology. In practice · 2019Article
- Body mass index trajectories in childhood is predictive of cardiovascular risk: results from the 23-year longitudinal Georgia Stress and Heart study.International journal of obesity (2005) · 2018Article
- Prevalence and Contributors to Low-grade Inflammation in Three U.S. Populations of Reproductive Age Women.Paediatric and perinatal epidemiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent longitudinal work suggests that weight change is an important risk factor for inflammation across the full range of BMI. However, few studies have examined whether the risk of inflammation differs by patterns of weight gain over time. Using latent class trajectory analysis, we test whether patterns of weight gain are associated with elevated high-sensitivity C-reactive protein (hs-CRP 2-10 mg/L). METHODS AND
resultsData come from China Health and Nutrition Survey (CHNS) participants (n=5536), aged 18 at baseline to 66 years in 2009, with measured weight over 18 years. Latent class trajectory analysis was used to identify weight-change trajectories in 6 age and sex strata. Multivariable general linear mixed-effects models fit with a logit link were used to assess the risk of elevated hs-CRP across weight trajectory classes. Models were fit within age and sex strata, controlling for baseline weight, adult height, and smoking, and included random intercepts to account for community-level correlation. Steeper weight-gain trajectories were associated with greater risk of elevated hs-CRP compared to more moderate weight-gain trajectories in men and women. Initially high weight gain followed by weight loss was associated with lower risk of elevated hs-CRP in women aged 18 to 40.
conclusionsLatent class trajectory analysis identified heterogeneity in adult weight change associated with differential risk of inflammation independently of baseline weight and smoking. These results suggest that trajectories of weight gain are an important clinical concern and may identify those at risk for inflammation and the development of cardiometabolic disease.
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