Evidence map›Paper›PMID 27638696›Full record

ReviewThe Biological bulletin2016

Imaging Adenosine Triphosphate (ATP).

Megha Rajendran, Eric Dane, Jason Conley, Mathew Tantama

Abstract readReview
In one paragraph

Review in The Biological bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. A Hitchhiker's Guide to Physical and Cognitive Effort.Sports medicine (Auckland, N.Z.) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Reagentless Real-Time ATP Monitoring with New DNA Aptamers.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Megha RajendranDepartment of Chemistry, Purdue University, 560 Oval Drive, Box 68, West Lafayette, Indiana 47907; and.
Eric DaneKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 76-211, Cambridge, Massachusetts 02139.
Jason ConleyDepartment of Chemistry, Purdue University, 560 Oval Drive, Box 68, West Lafayette, Indiana 47907; and.
Mathew TantamaDepartment of Chemistry, Purdue University, 560 Oval Drive, Box 68, West Lafayette, Indiana 47907; and mtantama@purdue.edu.

Funding

Optical Tools to Study Neuropeptide SignalingR21EY026425 · NEI · PURDUE UNIVERSITY · PI TANTAMA, MATHEW · 2015 to 2016
$454k
Genetically-encoded optical sensors to study purinergic signalingR21NS092010 · NINDS · PURDUE UNIVERSITY · PI TANTAMA, MATHEW · 2015 to 2016
$421k
NEI NIH HHS R21 EY026425NINDS NIH HHS R21 NS092010
6 · The paper itself

Abstract

Adenosine triphosphate (ATP) is a universal mediator of metabolism and signaling across unicellular and multicellular species. There is a fundamental interdependence between the dynamics of ATP and the physiology that occurs inside and outside the cell. Characterizing and understanding ATP dynamics provide valuable mechanistic insight into processes that range from neurotransmission to the chemotaxis of immune cells. Therefore, we require the methodology to interrogate both temporal and spatial components of ATP dynamics from the subcellular to the organismal levels in live specimens. Over the last several decades, a number of molecular probes that are specific to ATP have been developed. These probes have been combined with imaging approaches, particularly optical microscopy, to enable qualitative and quantitative detection of this critical molecule. In this review, we survey current examples of technologies available for visualizing ATP in living cells, and identify areas where new tools and approaches are needed to expand our capabilities.

Indexed as

Adenosine TriphosphateAnimalsAptamers, NucleotideBioluminescence Resonance Energy Transfer TechniquesFluorescence Resonance Energy TransferMicroscopyMolecular ImagingMolecular ProbesOptical ImagingAdenosine TriphosphateAptamers, NucleotideMolecular Probes

Identifiers

PMID27638696
PMCPMC5063237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.