ReviewJournal of pharmacokinetics and pharmacodynamics2016
Assessment of non-linear combination effect terms for drug-drug interactions.
Review in Journal of pharmacokinetics and pharmacodynamics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Robust prediction of drug combination side effects in realistic settings.PLoS computational biology · 2026Article
- On the existence conditions of interaction indices in response surface models.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Guiding model-driven combination dose selection using multi-objective synergy optimization.CPT: pharmacometrics & systems pharmacology · 2023Article
- A mechanistic assessment of the nature of pharmacodynamic drug-drug interaction in vivo and in vitro.In silico pharmacology · 2023Article
- Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease.Frontiers in medicine · 2023Article
- Pharmacodynamics and Bactericidal Activity of Combination Regimens in Pulmonary Tuberculosis: Application to Bedaquiline-Pretomanid-Pyrazinamide.Antimicrobial agents and chemotherapy · 2022Article
- Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine.International journal of molecular sciences · 2022Article
- Exposure-response modeling improves selection of radiation and radiosensitizer combinations.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV.Viruses · 2021Article
- OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control.Journal of optimization theory and applications · 2021Article
- Pharmacodynamic Drug-Drug Interactions.Clinical pharmacology and therapeutics · 2019Review
- Target-Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy.CPT: pharmacometrics & systems pharmacology · 2019Article
- Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction.British journal of pharmacology · 2018Article
- Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells.The AAPS journal · 2018Article
- Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations.The AAPS journal · 2018Article
- Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.Clinical pharmacokinetics · 2018Article
- Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.Clinical pharmacokinetics · 2018Review
- Model-Based Evaluation of Radiation and Radiosensitizing Agents in Oncology.CPT: pharmacometrics & systems pharmacology · 2018Article
- Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases.Journal of pharmacokinetics and pharmacodynamics · 2017Article
- Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells.Frontiers in pharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Drugs interact with their targets in different ways. A diversity of modeling approaches exists to describe the combination effects of two drugs. We investigate several combination effect terms (CET) regarding their underlying mechanism based on drug-receptor binding kinetics, empirical and statistical summation principles and indirect response models. A list with properties is provided and the interrelationship of the CETs is analyzed. A method is presented to calculate the optimal drug concentration pair to produce the half-maximal combination effect. This work provides a comprehensive overview of typically applied CETs and should shed light into the question as to which CET is appropriate for application in pharmacokinetic/pharmacodynamic models to describe a specific drug-drug interaction mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.