Evidence map›Paper›PMID 27638466›Full record

ArticleProtein & cell2016

C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans.

Lu Wang, Fei Xu, Guishuan Wang, Xiaorong Wang, Ajuan Liang, Hefeng Huang, Fei Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Efficient Knocking Out of the Organophosphorus Insecticides Degradation GeneInternational journal of molecular sciences · 2023
    Article
  2. Application ofInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lu WangInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China.
Fei XuSchool of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
Guishuan WangInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China.
Xiaorong WangInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China.
Ajuan LiangInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China.
Hefeng HuangInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China. huanghefg@sjtu.edu.cn.
Fei SunInternational Peace Maternity & Child Health Hospital, Shanghai Key laboratory for Reproductive Medicine, School of Medicine, Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiaotong University, Shanghai, 200030, China. sunfei@shsmu.edu.cn.
International Peace Maternity & Child Health Hospital · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reproduction, fat metabolism, and longevity are intertwined regulatory axes; recent studies in C. elegans have provided evidence that these processes are directly coupled. However, the mechanisms by which they are coupled and the reproductive signals modulating fat metabolism and lifespan are poorly understood. Here, we find that an oogenesis-enriched gene, c30f12.4, is specifically expressed and located in germ cells and early embryos; when the gene is knocked out, oogenesis is disrupted and brood size is decreased. In addition to the reproductive phenotype, we find that the loss of c30f12.4 alters fat metabolism, resulting in decreased fat storage and smaller lipid droplets. Meanwhile, c30f12.4 mutant worms display a shortened lifespan. Our results highlight an important role for c30f12.4 in regulating reproduction, fat homeostasis, and aging in C. elegans, which helps us to better understand the relationship between these processes.

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFemaleLipid DropletsLipid MetabolismLongevityMutationOogenesisCaenorhabditis elegans ProteinsC30F12.4fat metabolismlifespanoogenesis

Identifiers

PMID27638466
PMCPMC5055490
OpenAlexW2516919640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.