Evidence map›Paper›PMID 27638450›Full record

ArticleNeuropharmacology2016

Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system.

Li Wang, Luis E F Almeida, Margaret Nettleton, Alfia Khaibullina, Sarah Albani, Sayuri Kamimura, Mehdi Nouraie, Zenaide M N Quezado

Abstract read
In one paragraph

Article in Neuropharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Li WangThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Luis E F AlmeidaThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Margaret NettletonThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Alfia KhaibullinaThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Sarah AlbaniThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Sayuri KamimuraThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA.
Mehdi NouraieDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Zenaide M N QuezadoThe Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA; Center for Neuroscience Research, Children's Research Institute, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20010, USA. Electronic address: zquezado@childrensnational.org.
Children's National · USGeorge Washington University · USUniversity of Pittsburgh · US

Funding

NEUROIMAGING COREP30HD040677 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI MCCARTER, ROBERT JAMES · 2001 to 2015
$15.9M
Neurobiology of pain and behavior changes associated with rare diseases and developmental disabilitiesZIACL090052 · CLC · CLINICAL CENTER · PI QUEZADO, ZENAIDE · 2017 to 2025
$0k
NICHD NIH HHS P30 HD040677
6 · The paper itself

Abstract

Caretakers and clinicians alike have long recognized that individuals with autism spectrum disorder (ASD) can have altered sensory processing, which can contribute to its core symptoms. However, the pathobiology of sensory alterations in ASD is poorly understood. Here we examined nocifensive behavior in ASD mouse models, the BTBR T

Indexed as

AnimalsAutism Spectrum DisorderAvoidance LearningBrainDisease Models, AnimalFemaleFragile X Messenger Ribonucleoprotein 1MaleMiceMice, Inbred C57BLMice, KnockoutNicotineNicotinic AgonistsNociceptionProtein SubunitsReceptors, NicotinicFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1NicotineNicotinic AgonistsProtein SubunitsReceptors, NicotinicAutismBTBRnAChRNicotineNicotine (PubChem CID: 89594)NicotinicNociceptionNocifensivePainSaccharin (PubChem CID: 656582)Social behavior

Identifiers

PMID27638450
PMCPMC5075237
OpenAlexW2520744785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.